AMG-172
AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 (HY-19792) via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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SMILES
[AMG-172]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMG-172 Related Classifications
HY-185483 Related Classifications
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- AMG-172
- AMG172
- AMG 172
- Antibody-Drug Conjugates (ADCs)
- Transmembrane Glycoprotein
- Microtubule/Tubulin
- IgG1 monoclonal anti-CD27L antibody
- metaphase arrest
- MCC
- relapsed/refractory clear cell renal cell carcinoma
- antibody-drug conjugate
- microtubule assembly/disassembly dynamics
- CD27L-expressing cells
- maytansinoid cytotoxin DM1
- Inhibitor
- inhibitor
- inhibit