country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-179228

Copy Link Print Information

AN02

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1246964-08-8
화학식: C₁₉H₁₅Cl₂NO
분자량:344.23

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AN02 Chemical Structure

CAS No.: 1246964-08-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All TGF-beta/Smad Isoforms :

Smad1
Smad3

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human A549 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-231	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MDA-MB-231	IC₅₀	1.6 μM Compound: A2	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by CCK-8 assay	[PMID: 38746900]
MDA-MB-468	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MG-63	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MG-63 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
MV4-11	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human MV4-11 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H23	IC₅₀	0.39 μM Compound: 470	Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay Antiproliferative activity against human NCI-H23 cells assessed as cell viability by WST-1 assay	[PMID: 32172081]
NCI-H441	IC₅₀	5 μM Compound: 3	Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs Antiproliferative activity against human H441 cells assessed as decrease of hexosaminidase activity after 24 hrs	[PMID: 20638855]

Chemical Information

CAS No. 1246964-08-8
분자량 344.23
화학식 C₁₉H₁₅Cl₂NO
SMILES

ClC1=CC=CC=C1/C=C(C/2=O)\CNCC2=C/C3=C(Cl)C=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin H, et al. AN02, a Naovel Curcumin Derivative, Orchestrates APC-SMAD4-Mediated CTLA-4 Degradation for Ovarian Cancer Therapy. Mol Carcinog. 2025 Oct 21. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

AN02

All TGF-beta/Smad Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AN02 Related Classifications

HY-179228 Related Classifications