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Cat. No.: HY-146396

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Anticancer agent 51

Anticancer agent 51 (compound 3d) is a potent anticancer agent with an K_i of 731.62 nM. Anticancer agent 51 shows anticancer activity. Anticancer agent 51 has the potential for the research of prostate cancer.

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CAS No.: 2521777-38-6
화학식: C₂₂H₂₀F₃N₃O₂S
분자량:447.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Anticancer agent 51 Chemical Structure

CAS No.: 2521777-38-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
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Bioz

Biological Activity

제품 설명

All MetAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	62.2 μM Compound: 3d; SGK-606	Cytotoxicity against human DU-145 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human DU-145 cells assessed as reduction in cell viability by MTT assay	[PMID: 32998089]
LNCaP	IC₅₀	92.8 μM Compound: 3d; SGK-606	Cytotoxicity against human LNCaP cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human LNCaP cells assessed as reduction in cell viability by MTT assay	[PMID: 32998089]
PC-3	IC₅₀	64.3 μM Compound: 3d; SGK-606	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability by MTT assay	[PMID: 32998089]

In Vitro

Anticancer agent 51 (compound 3d) shows anticancer activity with IC₅₀s of 64.3, 62.2, 92.8 μM for PC-3, DU-145, LNCaP cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2521777-38-6
분자량 447.47
화학식 C₂₂H₂₀F₃N₃O₂S
SMILES

FC(F)(F)C(C=C1)=CC=C1NC(NNC([C@H](C2=CC3=C(C=C2)C=C(C=C3)OC)C)=O)=S
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Birgül K, et al. Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives. Eur J Med Chem. 2020 Dec 15;208:112841. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
순도&문서
References

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Anticancer agent 51

All MetAP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Anticancer agent 51 Related Classifications

HY-146396 Related Classifications