Antileukinate
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury.
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- CAS No.: 138559-60-1
- 화학식: C45H66N18O7S
- 분자량:1003.19
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM[2].
Antileukinate (10-100 μM; 2 hours) significantly suppresses eosinophil chemotaxis to human eotaxin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (20-25g)[1]
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Dosage:52.63 mg/kg
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Administration:Subcutaneous injection
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Result:Reduced pancreatic edema induced by Caerulein (50 μg/kg).
- Phagocytosis Functional Assay
- Cell migration
- Zigmond Chamber Chemotaxis Assay
- Under-Agarose Cell Migration Assay
- Carrageenan-Induced Paw Edema
- Transwell/Boyden Chamber Migration Assay
- Zymosan-Induced Peritonitis
- Research Protocol for Inflammation-related Diseases
- Dunn/Insall Chamber Chemotaxis Assay
Chemical Information
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CAS No. 138559-60-1
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분자량 1003.19
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화학식 C45H66N18O7S
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Sequence Shortening
Ac-RRWWCR-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138(1):40-8. [Content Brief]
[2]. Yuji Fukuno, et al. Chemokine receptor inhibitor, Antileukinate, suppressed ovalbumin-induced eosinophilic inflammation in the airway. Cytokine. 2003 Jun 7;22(5):116-25. [Content Brief]
[3]. S HayashiY, et al. Antileukinate, a hexapeptide inhibitor of CXC-chemokine receptor, suppresses bleomycin-induced acute lung injury in mice. Lung. 2002;180(6):339-48. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileukinate Related Classifications
HY-125567 Related Classifications
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