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United States

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Cat. No.: HY-151501

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Antimicrobial agent-11

Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₇₇H₆₁Cl₂F₁₇N₈O₂₄
분자량:1876.23

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Antimicrobial agent-11 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity^[1].

IC₅₀ & Target

Bacteria, SARS-CoV-2^[1]

In Vitro

Antimicrobial agent-11 (compound 5) shows inhibitory activity on coronavirus (SARS-CoV-2) replication and spike-mediated pseudovirus entry in Vero E6 cells and Calu-3 cells, with EC₅₀ values of 24 μM, 57μM^[1].
Antimicrobial agent-11 inhibits Cathepsin L, 3CL^Pro enzyme activity and the ACE2-spike interaction, with EC₅₀ values of 52 μM, 5 μM and 65 μM respectively^[1].
Antimicrobial agent-11 (0-10 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria^[1].
Antimicrobial agent-11 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

S. aureus, E. faecalis, E. faecium, S. epidermidis, S. haemolyticus
Concentration:

0-1 μg/mL approximately
Incubation Time:
Result:

Inhibited bacteria activities with MIC values of 0.25-7 μg/mL.

Chemical Information

분자량 1876.23
화학식 C₇₇H₆₁Cl₂F₁₇N₈O₂₄
SMILES

OC1=C(OC2=C(C=C(C=C2)[C@@]([H])(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(C)=O)[C@]([H])(NC([C@@H]4N5)=O)C(N[C@H](C6=CC(O)=CC(O)=C6C7=CC4=CC=C7O)C(O)=O)=O)Cl)C=C(C=C1OC8=C(C=C(C=C8)C[C@]([H])9NC([C@@H]%10NC(CCC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)C(F)(C(F)(F)F)F)F)F)F)F)F)=O)=O)Cl)[C@H](C5=O)NC([C@@H](NC9=O)C%11=CC(OC%12=CC%10=CC=C%12O)=CC(O)=C%11)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ilona Bereczki, et al. Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria. Sci Rep. 2022 Sep 26;12(1):16001. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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