country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-151339

Copy Link Print Information

Antitubercular agent-31

Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC₅₀ of 1.1 μM.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2764818-29-1
화학식: C₂₀H₂₄F₂N₄O₅S₂
분자량:502.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antitubercular agent-31 Chemical Structure

CAS No.: 2764818-29-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC₅₀: 1.1 μM (DprE1)^[1]

In Vitro

Antitubercular agent-31 (Compound 2) shows aqueous solubility of 0.81 μg/mL in phosphate buffer pH 7.4. The plasma protein binding property is 97.9%^[1].
Antitubercular agent-31 shows acceptable liver microsomal stability in human and mouse liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitubercular agent-31 (10 or 2 mg/kg; p.o. or i.v.; once) displays an acceptable pharmacokinetics (PK) profile with only dosing i.v., shows either poor membrane permeability or rapid clearance rate in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Balb/c mice^[1]
Dosage:

10 mg/kg or 2 mg/kg
Administration:

Oral (10 mg/kg) or intravenous (2 mg/kg) administration (Pharmacokinetic Analysis)

Result:

PK data for Antitubercular agent-31 (Compound 2),iv, 2mg/kg^[1].

T_max (h)	C_max (ng/mL)	AUC_0-t (h*ng/mL)	AUC_0-∞ (h*ng/mL)	T_1/2 (h)	CL/F (mL/h/kg)	MRT_0-∞ (h)
0.1±0.0	463.4±103.4	158.2±18.8	161.3±18.6	0.3±0.0	12515.5±1379.7	0.4±0.0

No compound signal was detected at oral administration.

Chemical Information

CAS No. 2764818-29-1
분자량 502.56
화학식 C₂₀H₂₄F₂N₄O₅S₂
SMILES

O=C1N=C(N2CCN(CC3CCC(F)(F)CC3)CC2)SC4=C([N+]([O-])=O)C=C(S(=O)(C)=O)C=C14
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shi R, et al. Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents. ACS Med Chem Lett. 2022 Mar 10;13(4):593-598. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기