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Cat. No.: HY-14142

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AP-24226

AP-24226 is a potent inhibitor of Scr/ABL.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 926922-22-7
화학식: C₂₄H₂₀F₃N₇O
분자량:479.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AP-24226 Chemical Structure

CAS No.: 926922-22-7

사이즈

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AP-24226 is a potent inhibitor of Scr/ABL^[1].

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	2746 nM Compound: 9i, AP24226	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	2746 nM Compound: Id	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	4.8 nM Compound: Id	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	4.8 μM Compound: 9i, AP24226	Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	4894 μM Compound: 9i, AP24226	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 19572547]
K562	IC₅₀	6.1 μM Compound: 9i, AP24226	Antiproliferative activity against human K562 cells after 3 days by MTS assay Antiproliferative activity against human K562 cells after 3 days by MTS assay	[PMID: 19572547]

Chemical Information

CAS No. 926922-22-7
분자량 479.46
화학식 C₂₄H₂₀F₃N₇O
SMILES

O=C(NC1=NC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(/C=C/N3C=NC4=C(NC5CC5)N=CN=C34)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang, W. S., et al., (2009). 9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: J. Med. Chem., 2009, 52 (15), pp 4743-4756 [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
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AP-24226

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AP-24226 Related Classifications

HY-14142 Related Classifications