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Cat. No.: HY-N12399

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Aplithianines A

Aplithianines A is a potent inhibitor against J-PKA_cα with an IC₅₀ of 1 μM , and inhibits wild-type PKA with an IC₅₀ of 84 nM. Aplithianines A inhibits J-PKAcα catalytic activity by competitively binding to the ATP pocket.

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CAS No.: 3027425-38-0
화학식: C₁₃H₁₃N₇S
분자량:299.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Aplithianines A Chemical Structure

CAS No.: 3027425-38-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

1 μM (J-PKAcα)^[1]

All PKA Isoforms :

Chemical Information

CAS No. 3027425-38-0
분자량 299.35
화학식 C₁₃H₁₃N₇S
SMILES

CN1C=NC=C1C(SCC2)=CN2C3=NC=NC4=C3N=CN4
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Microorganisms
Aplidium sp.
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Du L, et al. Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J Nat Prod. 2023;86(10):2283-2293. IF: 5.1 Q1 B2 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Aplithianines A

All PKA Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Aplithianines A Related Classifications

HY-N12399 Related Classifications