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Cat. No.: HY-181635

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Azapetine

Azapetine is an α-adrenergic receptor antagonist, with a IC₅₀ of 0.205 μM against rat α₁-adrenergic receptors and a IC₅₀ of 1.3 μM against rat α₂-adrenergic receptors. Azapetine blocks α1/α2-adrenergic receptor-mediated contraction of blood vessels and vascular smooth muscles. Azapetine can be used for the research of peripheral vascular diseases.

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CAS No.: 146-36-1
화학식: C₁₇H₁₇N
분자량:235.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Azapetine Chemical Structure

CAS No.: 146-36-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

rat α1-adrenergic receptor

0.205 μM (IC₅₀)

rat α2-adrenergic receptor

1.3 μM (IC₅₀)

All Adrenergic Receptor Isoforms :

In Vitro

Azapetine (45-60 min) exhibits higher binding affinity for α₁-adrenergic receptors than for α₂-adrenergic receptors in isolated rat brain cell membranes, with an IC₅₀ of 0.205 μM for α₁-adrenergic receptors and 1.3 μM for α₂-adrenergic receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Azapetine (intravenous administration) exhibits in vivo functional blockade selectivity for α₁-adrenergic receptors over α₂-adrenergic receptors in normotensive decerebrate-spinal Wistar rats, with a logarithmic selectivity ratio of 1.21^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 146-36-1
분자량 235.32
화학식 C₁₇H₁₇N
SMILES

C=CCN1CC2=C(C3=C(C1)C=CC=C3)C=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Timmermans PB, et al. Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. J Med Chem. 1984;27(4):495-503. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Azapetine

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Azapetine Related Classifications

HY-181635 Related Classifications