country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-165466

Copy Link Print Information

Azidothiorphan

Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a K_i value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 83960-29-6
화학식: C₁₂H₁₄N₄O₃S
분자량:294.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Azidothiorphan Chemical Structure

CAS No.: 83960-29-6

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Azidothiorphan (100 nM; 5 minutes) irreversibly inhibits enkephalinase from mouse striatal membranes (P₂ fraction) with 98% activity loss at 100 nM after 5 minutes of 254 nm irradiation^[1].
Azidothiorphan potently inhibits purified neutral endopeptidase 24.11 with a K_i of 0.75 nM and acts as an active-site-directed irreversible photoaffinity ligand for the enzyme^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Azidothiorphan (50 μg/mouse; intracerebroventricular injection) produces a long-lasting analgesic effect in mice, which does not disappear until 6 h later^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 83960-29-6
분자량 294.33
화학식 C₁₂H₁₄N₄O₃S
SMILES

[N-]=[N+]=NC1=CC=C(C=C1)CC(C(=O)NCC(=O)O)CS
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Roques BP, et al. New enkephalinase inhibitors as probes to differentiate "enkephalinase" and angiotensin-converting-enzyme active sites. Life Sci. 1982 Oct 18-25;31(16-17):1749-52. [Content Brief]

[2]. Beaumont A, et al. Irreversible photolabeling of active site of neutral endopeptidase-24.11 "enkephalinase" by azidothiorphan and [14C]-azidothiorphan. Molecular pharmacology. 1987 Nov;32(5):594-9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유