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Cat. No.: HY-163883

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BChE-IN-34

BChE-IN-34 is a potent and selective butyrylcholinesterase (BChE) inhibitor with an IIC₅₀ of 25 nM. BChE-IN-34 shows excellent selectivity against BChE over acetylcholinesterase. BChE-IN-34 has neuroprotective and antioxidant effects.

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CAS No.: 2215768-12-8
화학식: C₂₁H₁₉N₅O₂S₂
분자량:437.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BChE-IN-34 Chemical Structure

CAS No.: 2215768-12-8

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

eqBCHE

25 nM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

BChE-IN-34 (compound 35a) has moderate inhibition potency on β-Amyloid (1-42) (HY-P1363A) aggregation, and significant neuroprotective effect against SH-SY5Y cell injury induced by H₂O₂ and β-Amyloid (1-42)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2215768-12-8
분자량 437.54
화학식 C₂₁H₁₉N₅O₂S₂
SMILES

O=C(CSC1=NN=C(COC2=CC=CC3=C2C=CC=C3)N1CC=C)NC4=NC=CS4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ebru Koçak Aslan, et al. Novel 1,2,4-triazole derivatives containing the naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, and biological evaluation. Arch Pharm (Weinheim). 2024 Jul 21:e2400406. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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BChE-IN-34

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BChE-IN-34 Related Classifications

HY-163883 Related Classifications