BChE-IN-48
BChE-IN-48 (Compound 12a) is a BChE inhibitor that can cross the blood-brain barrier with IC50 values for eqBChE and huBChE of 1.3 and 0.95 μM respectively. BChE-IN-48 exhibits an IC50 value for eeAChE of 8.6 μM. BChE-IN-48 exhibits significant neuroprotective activity in cell damage and significantly improves cognitive impairment in mouse models. BChE-IN-48 can be used for research on Alzheimer's disease.
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- 화학식: C25H32N2O4
- 분자량:424.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
|
hBCHE 0.95 μM (IC50) |
eqBCHE 1.3 μM (IC50) |
eel AChE 8.6 μM (IC50) |
Chemical Information
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분자량 424.53
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화학식 C25H32N2O4
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SMILES
COC1=C(OC(N(C)C)=O)C=CC(CCC(N2CCC(CC3=CC=CC=C3)CC2)=O)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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