BE2012
Based on 1 Customer Validation
BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels.
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- Purity: 99.49%
- CAS No.: 667889-47-6
- 화학식: C18H19N3O
- 분자량:293.36
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
REV-ERBα 0.285 μM (EC50) |
REV-ERBβ 0.346 μM (EC50) |
Parmacokinetics
| Species | Dose | Route | Cmax | Tmax | T1/2 | AUC0-last | CL | Vd |
|---|---|---|---|---|---|---|---|---|
| Mice[1] | 30 mg/kg | i.p. | 1560 ng/mL | 0.5 h | 3.79 h | 4023 h·ng/g | 7.4 L/h/kg | 40.5 L/kg |
Chemical Information
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CAS No. 667889-47-6
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Appearance Solid
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분자량 293.36
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화학식 C18H19N3O
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Color White to light yellow
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SMILES
CC(C)(C)C(C=C1)=CC=C1C(N2N)=NC3=CC=CC=C3C2=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
In Vitro:
DMSO : 20 mg/mL (68.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4088 mL | 17.0439 mL | 34.0878 mL | 85.2195 mL |
| 5 mM | 0.6818 mL | 3.4088 mL | 6.8176 mL | 17.0439 mL | |
| 10 mM | 0.3409 mL | 1.7044 mL | 3.4088 mL | 8.5220 mL | |
| 15 mM | 0.2273 mL | 1.1363 mL | 2.2725 mL | 5.6813 mL | |
| 20 mM | 0.1704 mL | 0.8522 mL | 1.7044 mL | 4.2610 mL | |
| 25 mM | 0.1364 mL | 0.6818 mL | 1.3635 mL | 3.4088 mL | |
| 30 mM | 0.1136 mL | 0.5681 mL | 1.1363 mL | 2.8407 mL | |
| 40 mM | 0.0852 mL | 0.4261 mL | 0.8522 mL | 2.1305 mL | |
| 50 mM | 0.0682 mL | 0.3409 mL | 0.6818 mL | 1.7044 mL | |
| 60 mM | 0.0568 mL | 0.2841 mL | 0.5681 mL | 1.4203 mL |
BE2012 Related Classifications
HY-180944 Related Classifications
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