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Cat. No.: HY-117893

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BIM-46068

BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC₅₀ = 91.4 nM). BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer.

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CAS No.: 201487-53-8
화학식: C₂₁H₄₂N₄O₃S₃
분자량:494.78

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

BIM-46068 Chemical Structure

CAS No.: 201487-53-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Ras Isoforms :

In Vitro

BIM-46068 (0.1-10 µM, 48 h) specifically inhibits the processing of Ras in MiaPaCa-2 cancer cells^[1].
BIM-46068 (96 h) inhibits the growth of cells bearing the wild-type ras as well as cells with the different mutated ras (K-ras, N-ras, or H-ras) and effectively inhibits the multidrug-resistant cell line T24R^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MiaPaCa-2 cells
Concentration:

0.1 µM, 1 µM, 10 µM
Incubation Time:

48 h
Result:

Caused a change in the electrophoretic migration rate of H-Ras protein in MiaPaCa-2 cells, from rapid migration (farnesylated form) to slow migration (unfarnesylated form).

In Vivo

BIM-46068 (1-30 mg/kg, i.p., once daily for 10 days) significantly reduces tumor growth in a dose-dependent manner, and no signs of toxicity, such as weight loss or death, are observed at the highest dose (30 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice were implanted s.c. with MiaPaCa-2 cells (5 × 10⁶), a human pancreatic tumor cell line expressing mutated K-ras^[1].
Dosage:

1 mg/kg, 10 mg/kg, 30 mg/kg
Administration:

I.p., once daily for 10 days
Result:

Significantly reduced tumor growth in a dose-dependent manner.
On day 34 post-implantation, the mean tumor volume in the 30 mg/kg group was reduced by 50% compared to the control group.

Chemical Information

CAS No. 201487-53-8
분자량 494.78
화학식 C₂₁H₄₂N₄O₃S₃
SMILES

CSCC[C@@H](C(OC)=O)NC([C@H]1N(C[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CSC1(C)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Prevost GP, et al. Inhibition of human tumor cell growth in vitro and in vivo by a specific inhibitor of human farnesyltransferase: BIM-46068. Int J Cancer. 1999 Oct 8;83(2):283-7. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

BIM-46068

All Ras Isoforms