BMT-297376
Based on 1 Customer Validation
BMT-297376 is an optimized derivative of Linrodostat (HY-101560). BMT-297376 inhibits IDO1 and the ubiquinone (Q) site of mitochondrial respiratory chain complex I. BMT-297376 is suitable for tumor immunology-related research.
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- Purity: 99.14%
- CAS No.: 2251031-81-7
- 화학식: C23H29F2N3O3
- 분자량:433.49
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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IDO1 |
BMT-297376 (BMT) (1-64 μM) potently inhibits mitochondrial complex I activity in isolated mitochondria with an IC50 of 9.9 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2251031-81-7
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Appearance Solid
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분자량 433.49
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화학식 C23H29F2N3O3
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Color White to off-white
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SMILES
FC(C1=C(OC)N=CC=C1[C@H]2CC[C@@](CC2)([H])[C@@H](CC)NC(C3=CN=C(OC)C=C3)=O)F
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
Methanol : ≥ 100 mg/mL (230.69 mM)
DMSO : 100 mg/mL (230.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol / DMSO | 1 mM | 2.3069 mL | 11.5343 mL | 23.0686 mL | 57.6715 mL |
| 5 mM | 0.4614 mL | 2.3069 mL | 4.6137 mL | 11.5343 mL | |
| 10 mM | 0.2307 mL | 1.1534 mL | 2.3069 mL | 5.7671 mL | |
| 15 mM | 0.1538 mL | 0.7690 mL | 1.5379 mL | 3.8448 mL | |
| 20 mM | 0.1153 mL | 0.5767 mL | 1.1534 mL | 2.8836 mL | |
| 25 mM | 0.0923 mL | 0.4614 mL | 0.9227 mL | 2.3069 mL | |
| 30 mM | 0.0769 mL | 0.3845 mL | 0.7690 mL | 1.9224 mL | |
| 40 mM | 0.0577 mL | 0.2884 mL | 0.5767 mL | 1.4418 mL | |
| 50 mM | 0.0461 mL | 0.2307 mL | 0.4614 mL | 1.1534 mL | |
| 60 mM | 0.0384 mL | 0.1922 mL | 0.3845 mL | 0.9612 mL | |
| 80 mM | 0.0288 mL | 0.1442 mL | 0.2884 mL | 0.7209 mL | |
| 100 mM | 0.0231 mL | 0.1153 mL | 0.2307 mL | 0.5767 mL |
BMT-297376 Related Classifications
HY-139205 Related Classifications
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