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Cat. No.: HY-150908

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Brigatinib A

Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2 (HY-174368).

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CAS No.: 1197958-90-9
화학식: C₂₃H₂₈ClN₆O₂P
분자량:486.93

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Brigatinib A Chemical Structure

CAS No.: 1197958-90-9

사이즈

가격

재고

수량

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2 (HY-174368)^[1].

IC₅₀ & Target^[1]

EML4-ALK

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1975	IC₅₀	0.88 μM Compound: BA	Inhibition of cell viability in human NCI-H1975 cells incubated for 48 to 72 hrs by CCK8 assay Inhibition of cell viability in human NCI-H1975 cells incubated for 48 to 72 hrs by CCK8 assay	[PMID: 39114932]
NCI-H3122	IC₅₀	0.3 μM Compound: BA	Inhibition of cell viability in human NCI-H3122 cells incubated for 48 to 72 hrs by CCK8 assay Inhibition of cell viability in human NCI-H3122 cells incubated for 48 to 72 hrs by CCK8 assay	[PMID: 39114932]
SR	IC₅₀	1.6 nM Compound: 1	Antiproliferative activity against human SR cells assessed as reduction in cell growth Antiproliferative activity against human SR cells assessed as reduction in cell growth	[PMID: 32179332]

Chemical Information

CAS No. 1197958-90-9
분자량 486.93
화학식 C₂₃H₂₈ClN₆O₂P
SMILES

COC1=CC(N2CCNCC2)=CC=C1NC3=NC=C(C(NC4=CC=CC=C4P(C)(C)=O)=N3)Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang J, et al. Linker-free PROTACs efficiently induce the degradation of oncoproteins. Nat Commun. 2025 May 23;16(1):4794. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
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Brigatinib A

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Brigatinib A Related Classifications

HY-150908 Related Classifications