Crizotinib (Standard)

(Synonyms: PF-02341066 (Standard))

Crizotinib (Standard) is the analytical standard of Crizotinib. This product is intended for research and analytical applications. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

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  • CAS No.: 877399-52-5
  • 화학식: C21H22Cl2FN5O
  • 분자량:450.34
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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100 mg

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