country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-120131

Copy Link Print Information

Cyanofenphos

Cyanofenphos is an orally active organophosphate insecticide and brain AChE inhibitor with neurotoxicity. Cyanofenphos induces delayed neurotoxicity such as ataxia and paralysis. Cyanofenphos also causes symptoms including somnolence, reduced feed intake and weight loss in hens. Cyanofenphos has a unique self-antagonistic effect: repeated low-dose pre-treatment not only reduces subsequent acute toxicity, but also exacerbates delayed neurotoxicity and attenuates enzyme inhibition, with the protective effect peaking at 24 h after the last pre-treatment. Cyanofenphos is commonly used in studies related to delayed neurotoxicity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 13067-93-1
화학식: C₁₅H₁₄NO₂PS
분자량:303.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyanofenphos Chemical Structure

CAS No.: 13067-93-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

AChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vivo

Cyanofenphos (10-20 mg/kg; p.o.; daily; 8 days) pretreatment significantly reduces the acute toxicity of subsequent high-dose cyanofenphos in hens, increasing the LD₅₀ from 700 to 1170 mg/kg and reducing 7-day mortality from 77% to 20% following a 1000 mg/kg challenge^[1].
Cyanofenphos (80 mg/kg; oral; single dose) induces delayed neurotoxicity in hens following cyanofenphos challenge doses, with higher neurotoxicity incidence observed for 200 mg/kg compared to 100 mg/kg challenge doses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Domestic hens (2-3 months old, body weight 1.30-2.00 kg)^[2]
Dosage:

80 mg/kg (pretreatment); 100 mg/kg, 200 mg/kg (challenge)
Administration:

oral; single dose (pretreatment); oral; single dose (challenge, 24 hours or 8 days after pretreatment)
Result:

Resulted in 0 acute deaths and 20% (2/10 hens) developing slight ataxia for 100 mg/kg challenge at 24-hour interval.
Resulted in 0 acute deaths and 10% (1/10 hens) developing slight ataxia for 100 mg/kg challenge at 8-day interval.
Resulted in 0 acute deaths and 80% (8/10 hens) developing ataxia for 200 mg/kg challenge at 24-hour interval.
Resulted in 1 acute death and 89% (8/9 surviving hens) developing neurotoxicity for 200 mg/kg challenge at 8-day interval.

Chemical Information

CAS No. 13067-93-1
분자량 303.32
화학식 C₁₅H₁₄NO₂PS
SMILES

N#CC1=CC=C(OP(=S)(OCC)C=2C=CC=CC2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Konno N, et al. Protective effect of pretreatment against the acute toxicity of formulated cyanofenphos in hens. Tohoku J Exp Med. 1984;142(2):155-163. [Content Brief]

[2]. Yamauchi T, et al. Intensifying effect of repeated pretreatment for delayed neurotoxicity from organophosphorus insecticide cyanofenphos in hens[J]. Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 1984, 39(3): 611-620.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Cyanofenphos

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Cyanofenphos Related Classifications

HY-120131 Related Classifications