(D)-PPA 1
(D)-PPA 1 is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy.
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- CAS No.: 1620813-53-7
- 화학식: C70H98N20O21
- 분자량:1555.65
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
(D)-PPA 1 (0.2 mg/mL, 1.0 mg/mL) blocks the interaction between PD-1/PD-L1 at 1.0 mg/mL[1].
(D)-PPA 1 (3.125-100 μM; 24 h, 48 h) doesn’t kill tumor cells directly with no affect on CT26 cells growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CT26 cells
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Concentration:3.125, 6.25, 12.5, 25, 50, and 100 μM
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Incubation Time:24 hours, 48 hours
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Result:Left tumor cells growing normally.
(D)-PPA 1 (40 μg/mouse in 200 μL; i.v.; single dose) has the ability to target to tumor tissue in CT26-tumor-bearing mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CT26-tumor-bearing Balb/c mice[1]
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Dosage:2 mg/kg
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Administration:1) Subcutaneous injection, for around the tumor once every day for 7 days
2) Intraperitoneal injection, once every day for 7 days 3) Intraperitoneal injection, once every day for 12 days; recorded the survival on day 13 -
Result:Inhibited tumor growth, and prolonged the survival in mice.
Chemical Information
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CAS No. 1620813-53-7
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분자량 1555.65
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화학식 C70H98N20O21
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Sequence
D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe}
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Sequence Shortening
D-{NYSKPTDRQYHF}
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(D)-PPA 1 Related Classifications
HY-P4072 Related Classifications
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