D-Ribose-d5
Based on 1 Customer Validation
D-Ribose-d5 is the deuterium labeled D-Ribose. D-Ribose is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose is active in protein gl
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- Purity: 99.10%
- CAS No.: 372177-01-0
- 화학식: C5H5D5O5
- 분자량:155.16
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 372177-01-0
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Unlabeled Cas 50-69-1
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Appearance Solid
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분자량 155.16
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화학식 C5H5D5O5
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Color White to off-white
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SMILES
O[C@@]([C@]([C@](C([2H])([2H])O)([2H])O)([2H])O)([2H])C=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : ≥ 100 mg/mL (644.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (644.50 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Hong J, et al. D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res. 2018 Aug;41(8):838-847. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 6.4450 mL | 32.2248 mL | 64.4496 mL | 161.1240 mL |
| 5 mM | 1.2890 mL | 6.4450 mL | 12.8899 mL | 32.2248 mL | |
| 10 mM | 0.6445 mL | 3.2225 mL | 6.4450 mL | 16.1124 mL | |
| 15 mM | 0.4297 mL | 2.1483 mL | 4.2966 mL | 10.7416 mL | |
| 20 mM | 0.3222 mL | 1.6112 mL | 3.2225 mL | 8.0562 mL | |
| 25 mM | 0.2578 mL | 1.2890 mL | 2.5780 mL | 6.4450 mL | |
| 30 mM | 0.2148 mL | 1.0742 mL | 2.1483 mL | 5.3708 mL | |
| 40 mM | 0.1611 mL | 0.8056 mL | 1.6112 mL | 4.0281 mL | |
| 50 mM | 0.1289 mL | 0.6445 mL | 1.2890 mL | 3.2225 mL | |
| 60 mM | 0.1074 mL | 0.5371 mL | 1.0742 mL | 2.6854 mL | |
| 80 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0140 mL | |
| 100 mM | 0.0644 mL | 0.3222 mL | 0.6445 mL | 1.6112 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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