Difludiazepam
Difludiazepam (Ro 07-4065), a benzodiazepine derivative, is a GABAA receptor ligand with an IC50 of 4.1 nM. Difludiazepam binds to an allosteric site on the GABAA receptor to potentiate the receptor's response to GABA, reducing neuron excitability. Difludiazepam contains halogenated groups at the ortho position of its phenyl ring.
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- CAS No.: 39080-67-6
- 화학식: C16H11ClF2N2O
- 분자량:320.72
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
GABAA Receptor[1]
Difludiazepam exhibits a predicted GABAA receptor binding affinity (log 1/c = 9.16) that is greater than the previously reported highest predicted binding affinity for designer benzodiazepines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 39080-67-6
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Appearance Solid
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분자량 320.72
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화학식 C16H11ClF2N2O
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Color White to off-white
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SMILES
ClC1=CC(C(C2=C(C=CC=C2F)F)=NCC3=O)=C(N3C)C=C1
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Synonyms
Ro 07-4065
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMF : 15 mg/mL (46.77 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (288 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Manchester KR, et al. The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines. Forensic Toxicol. 2022 Jul;40(2):349-356. [Content Brief]
[2]. So SS, et al. Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem. 1996 Dec 20;39(26):5246-56. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 3.1180 mL | 15.5899 mL | 31.1798 mL | 77.9496 mL |
| 5 mM | 0.6236 mL | 3.1180 mL | 6.2360 mL | 15.5899 mL | |
| 10 mM | 0.3118 mL | 1.5590 mL | 3.1180 mL | 7.7950 mL | |
| 15 mM | 0.2079 mL | 1.0393 mL | 2.0787 mL | 5.1966 mL | |
| 20 mM | 0.1559 mL | 0.7795 mL | 1.5590 mL | 3.8975 mL | |
| 25 mM | 0.1247 mL | 0.6236 mL | 1.2472 mL | 3.1180 mL | |
| 30 mM | 0.1039 mL | 0.5197 mL | 1.0393 mL | 2.5983 mL | |
| 40 mM | 0.0779 mL | 0.3897 mL | 0.7795 mL | 1.9487 mL |
Difludiazepam Related Classifications
HY-124467 Related Classifications
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