(-)-DMNP
(-)-DMNP is an inhibitor targeting RelZ and Rel_Msm, with activity against mycobacteria. (-)-DMNP binds to structurally similar sites of RelZ and Rel_Msm, thereby inhibiting (p) ppGpp synthesis activity. (-)-DMNP inhibits the formation of persistent mycobacterial cells and eradicates their biofilms. (-)-DMNP can be used in the research of bacterial infections and tuberculosis.
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- 화학식: C17H24O2
- 분자량:260.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
(-)-DMNP (1.06 mM; 0-48 h) potently reduces persister cell survival in stationary-phase Mycobacterium smegmatis mc2 155 cells, with greater activity than racemic DMNP and no activity observed from the (+)-DMNP enantiomer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mycobacterium smegmatis mc2 155 wild-type strain
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Concentration:1.06 mM
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Incubation Time:0-48 h
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Result:Reduced survivor cell numbers in stationary-phase cells, with survival declining to near undetectable levels by 24 h.
Exhibited slightly greater activity than racemic DMNP mixture.
Showed far greater activity than (+)-DMNP, which had no noticeable antipersister activity.
Chemical Information
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분자량 260.37
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화학식 C17H24O2
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SMILES
C[C@@H]1CC[C@]([C@H](C)CCC(O)=O)([H])C2=CC(C)=CC=C21
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-DMNP Related Classifications
HY-186290 Related Classifications
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