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Cat. No.: HY-161731

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DS08701581

DS08701581 is an inhibitor of FER tyrosine kinase with IC₅₀. DS08701581 has anti-tumor activity and oral activity.

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CAS No.: 3074776-78-3
화학식: C₂₆H₃₂N₈O₂
분자량:488.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

DS08701581 Chemical Structure

CAS No.: 3074776-78-3

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

DS08701581 is an inhibitor of FER tyrosine kinase with IC₅₀. DS08701581 has anti-tumor activity and oral activity^[1].

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	0.67 nM Compound: 17c; DS08701581	Inhibition of cell viability in mouse BaF3 cells expressing FER incubated for 3 days by Cell Titer Glo assay Inhibition of cell viability in mouse BaF3 cells expressing FER incubated for 3 days by Cell Titer Glo assay	[PMID: 39015278]
BaF3	GI₅₀	1000 nM Compound: 17c; DS08701581	Inhibition of cell viability in mouse BaF3 cells incubated for 3 days by Cell Titer Glo assay Inhibition of cell viability in mouse BaF3 cells incubated for 3 days by Cell Titer Glo assay	[PMID: 39015278]

Chemical Information

CAS No. 3074776-78-3
분자량 488.58
화학식 C₂₆H₃₂N₈O₂
SMILES

O=C1NN=CC2=C(C#N)C(N[C@H]3[C@@H](N)CCCC3)=NC(NC4=CC=CC(N5C[C@H](C)O[C@H](C)C5)=C4)=C21
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Toru Taniguchi, et al. Optimization of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors, Leading to the Potent DS08701581. ACS Med. Chem. Lett. 2024

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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DS08701581

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DS08701581 Related Classifications

HY-161731 Related Classifications