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Cat. No.: HY-131206

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DS37571084

DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC₅₀ value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism.

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CAS No.: 2460353-87-9
화학식: C₂₈H₃₀Cl₂N₄O₂
분자량:525.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

DS37571084 Chemical Structure

CAS No.: 2460353-87-9

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PTH1R

0.17 μM (IC₅₀)

All PTHR Isoforms :

PTH1R
PTH2R

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	0.17 μM Compound: 12; DS37571084	Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins	[PMID: 32345459]

Chemical Information

CAS No. 2460353-87-9
분자량 525.47
화학식 C₂₈H₃₀Cl₂N₄O₂
SMILES

O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Arai Y, et al. Discovery of novel, potent, and orally bioavailable pyrido[2,3-d][1]benzazepin-6-one antagonists for parathyroid hormone receptor 1. Bioorg Med Chem. 2020 Jun 1;28(11):115524. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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CAS No.:
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Purity:
수량:

DS37571084

All PTHR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DS37571084 Related Classifications

HY-131206 Related Classifications