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Cat. No.: HY-161660

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DS44470011

DS44470011 is a hypoxia-inducing factor prolyl hydroxylase (HIF-PHD) inhibitor. DS44470011 has oral activity. DS44470011 promotes cell release of erythropoietin (EPO). DS44470011 can be used in the research of renal anemia.

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CAS No.: 1192586-35-8
화학식: C₂₁H₁₉N₃O₄
분자량:377.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DS44470011 Chemical Structure

CAS No.: 1192586-35-8

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수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

HIF-PHD

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	EC₅₀	8.4 μM Compound: 7; DS44470011	Hepatoprotective activity against human Hep3B cells assessed as increase of erythropoietin release by measuring effective concentration Hepatoprotective activity against human Hep3B cells assessed as increase of erythropoietin release by measuring effective concentration	[PMID: 38754564]

Chemical Information

CAS No. 1192586-35-8
분자량 377.39
화학식 C₂₁H₁₉N₃O₄
SMILES

OC1=C(C(NCC(O)=O)=O)N=C(CC2=CC=C(C3=CC=CC=C3)C=C2)N=C1C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. ukuda T,et al. Discovery of DS44470011: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia. Bioorg Med Chem Lett. 2024 Aug 1;108:129799. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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DS44470011

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DS44470011 Related Classifications

HY-161660 Related Classifications