Erythromycin lactobionate
Based on 24 publication(s) in Google Scholar
Erythromycin lactobionate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid[1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research[3][4].
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- CAS No.: 3847-29-8
- 화학식: C49H89NO25
- 분자량:1092.22
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Erythromycin lactobionate
More- Acta Pharm Sin B. 2021 Sep;11(9):2850-2858. [Abstract]
- Theranostics. 2022 Jan 1;12(3):1187-1203. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
- Biofabrication. 2023 Aug 21;15(4). [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Emerg Contam. 2026 Feb 23.
- J Med Chem. 2022 Mar 10;65(5):3894-3912. [Abstract]
- J Chem Inf Model. 2021 Apr 26;61(4):2016-2025. [Abstract]
- mLife. 2023 Feb 11;2(1):58-72. [Abstract]
- Aquat Toxicol. 2025 Feb 9:280:107284. [Abstract]
- BMC Microbiol. 2023 Apr 20;23(1):109. [Abstract]
- Environ Microbiol. 2021 Feb;23(2):696-712. [Abstract]
- Microbiol Spectr. 2025 Aug 29:e0059025. [Abstract]
- Microbiol Spectr. 2022 Feb 23;10(1):e0099121. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- Viruses. 2019 Nov 15;11(11):1064. [Abstract]
- Water. 2025 Jun 6.
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- bioRxiv. 2024 May 10.
- Research Square Print. December 5th, 2022.
- Charles University. 2020 Jul.
- Research Square Preprint. 2020 Jun.
Customer Validation & Images
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Microbiological Assay
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RT-PCR
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Microbiological Assay
All Antibiotic Isoforms
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Biological Activity
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Macrolide |
Erythromycin lactobionate inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively[1]. Erythromycin lactobionate (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (p<0.01) and 8-OHdG (p<0.01), reduces Iba-1 (p<0.01) and TNF-α (p<0.01) expression significantly[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Embryos primary cortical neuron (from the cerebral cortices of 17-day-old Sprague-Dawley rat)
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Concentration:10, 100 μM
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Incubation Time:24, 72 hours
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Result:Improved the viability of cultured neuronal cells in vitro after 3 hours oxygen-glucose deprivation (OGD).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female ddY mice (6 week-old) with EAC cells or CDF mice (6 week-old) with P388 cells[3]
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Dosage:0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
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Administration:Gastric intubation; 30-120 days
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Result:Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortened the MST in tumorbearing mice.
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Animal Model:Male Sprague-Dawley rats (8-week-old, 250-300 g)[4]
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Dosage:50 mg/kg
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Administration:Subcutaneous single injection
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Result:Reduced infarct volume and edema volume, improved neurological deficit.
Chemical Information
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CAS No. 3847-29-8
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Appearance Solid
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분자량 1092.22
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화학식 C49H89NO25
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Color White to off-white
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SMILES
C[C@@H]([C@@H]([C@H](C(O[C@@H]1CC)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](C([C@@H]([C@@H](O)[C@@]1(O)C)C)=O)C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)([H])[C@@H]3O.O[C@H]([C@@H](O)C(O)=O)[C@]([C@H](O)CO)([H])O[C@@H]([C@@H]([C@@H](O)[C@H]4O)O)O[C@@H]4CO
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (24)
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Journal Impact Factor
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Most Recent
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Acta Pharm Sin B
Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2. [Abstract]2021 Sep;11(9):2850-2858. PMID: 33723501 -
Theranostics
Antibiotic Azithromycin inhibits brown/beige fat functionality and promotes obesity in human and rodents. [Abstract]2022 Jan 1;12(3):1187-1203. PMID: 35154482
Erythromycin lactobionate purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Jan 1;12(3):1187-1203. [Abstract]
mRNA levels of thermogenic and mitochondrial gene programs in immortal beige and brown adipocytes treated with controls,erythromycin, azithromycin roxithromycin and telithromyc at 5 uM for 24 h (n=3).
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EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337
Erythromycin lactobionate purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Apr;78:103943. [Abstract]
FIC indices of the combination of plumbagin (32 μg/mL) and Erythromycin against tet(X3)/tet(X4)-positive strains. Synergy was defined as an FIC index of ≤ 0.5.
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299 -
Biofabrication
Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly. [Abstract]2023 Aug 21;15(4). PMID: 37552975 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
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J Med Chem
Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. [Abstract]2022 Mar 10;65(5):3894-3912. PMID: 35080871 -
J Chem Inf Model
Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Experimental Validation. [Abstract]2021 Apr 26;61(4):2016-2025. PMID: 33734704 -
mLife
LipR functions as an intracellular pH regulator in Bacillus thuringiensis under glucose conditions. [Abstract]2023 Feb 11;2(1):58-72. PMID: 38818337 -
Aquat Toxicol
Antibacterials exert toxic effects on aquatic organisms by inhibiting respiration, inducing oxidative stress, mitochondrial dysfunction and autophagy. [Abstract]2025 Feb 9:280:107284. PMID: 39951902 -
BMC Microbiol
The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin. [Abstract]2023 Apr 20;23(1):109. PMID: 37081393 -
Environ Microbiol
Expression of ribosomal protection protein RppA is regulated by a ribosome-dependent ribo-regulator and two mistranslation products. [Abstract]2021 Feb;23(2):696-712. PMID: 32592275 -
Microbiol Spectr
2025 Aug 29:e0059025. PMID: 40879403 -
Microbiol Spectr
The Mechanism of Action of Ginkgolic Acid (15:1) against Gram-Positive Bacteria Involves Cross Talk with Iron Homeostasis. [Abstract]2022 Feb 23;10(1):e0099121. PMID: 35019708 -
AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Erythromycin lactobionate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.
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Viruses
Erythromycin Estolate Inhibits Zika Virus Infection by Blocking Viral Entry as a Viral Inactivator. [Abstract]2019 Nov 15;11(11):1064. PMID: 31731598 -
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Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
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용액&용해도
H2O : ≥ 100 mg/mL (91.56 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (282 KB)
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SDS (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Gribble MJ, et al. Erythromycin. Med Clin North Am. 1982 Jan;66(1):79-89. [Content Brief]
[2]. Nakornchai S, et al. Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro. Acta Trop. 2006 Dec;100(3):185-91. Epub 2006 Nov 28. [Content Brief]
[3]. Hamada K, et al. Antitumor effect of erythromycin in mice. Chemotherapy. 1995 Jan-Feb. 41(1):59-69. [Content Brief]
[4]. Katayama Y, et al. Neuroprotective effects of erythromycin on cerebral ischemia reperfusion-injury and cell viability after oxygen-glucose deprivation in cultured neuronal cells. Brain Res. 2014 Nov 7. 1588:159-67. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.9156 mL | 4.5778 mL | 9.1557 mL | 22.8892 mL |
| 5 mM | 0.1831 mL | 0.9156 mL | 1.8311 mL | 4.5778 mL | |
| 10 mM | 0.0916 mL | 0.4578 mL | 0.9156 mL | 2.2889 mL | |
| 15 mM | 0.0610 mL | 0.3052 mL | 0.6104 mL | 1.5259 mL | |
| 20 mM | 0.0458 mL | 0.2289 mL | 0.4578 mL | 1.1445 mL | |
| 25 mM | 0.0366 mL | 0.1831 mL | 0.3662 mL | 0.9156 mL | |
| 30 mM | 0.0305 mL | 0.1526 mL | 0.3052 mL | 0.7630 mL | |
| 40 mM | 0.0229 mL | 0.1144 mL | 0.2289 mL | 0.5722 mL | |
| 50 mM | 0.0183 mL | 0.0916 mL | 0.1831 mL | 0.4578 mL | |
| 60 mM | 0.0153 mL | 0.0763 mL | 0.1526 mL | 0.3815 mL | |
| 80 mM | 0.0114 mL | 0.0572 mL | 0.1144 mL | 0.2861 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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