Fentonium bromide
Based on 1 Customer Validation
Fentonium bromide is an anti-ulcerogenic, anticholinergic and antispasmodic agent. Fentonium bromide can be used in the research of neurological conditions, such as unstable bladder.
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- Purity : 98.75%
- CAS No.: 5868-06-4
- 화학식: C31H34BrNO4
- 분자량:564.51
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vivo
Fentonium bromide (phentonium, 1 mg/kg, i.p.) prevents stress ulcers in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bethanechol-, pentagastrin-, and caerulein-induced gastric secretion in rats[1]
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Dosage:1 mg/kg
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Administration:Intravenous injection (i.v.)
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Result:Inhibited gastric acid secretion.
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Animal Model:Rats[2]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Decreased both the number of pre-ulceral lesions and the number of gastroduodenal ulcers in comparison with untreated controls.
Chemical Information
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CAS No. 5868-06-4
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Appearance Solid
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분자량 564.51
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화학식 C31H34BrNO4
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Color White to off-white
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SMILES
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)C[N+](C(CC3)CC4OC(C(C5=CC=CC=C5)CO)=O)(C3C4)C.[Br-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
In Vitro:
DMSO : 130 mg/mL (230.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. M Impicciatore, et al. Inhibitory effect of fentonium on gastric acid secretion in different laboratory animals. Farmaco Sci. 1977 Jul;32(7):482-9. [Content Brief]
[2]. Milani R, et al. A double-blind trial of fentonium bromide in the treatment of incontinent unstable bladder. Int J Clin Pharmacol Ther Toxicol. 1986 Aug;24(8):421-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7714 mL | 8.8572 mL | 17.7145 mL | 44.2862 mL |
| 5 mM | 0.3543 mL | 1.7714 mL | 3.5429 mL | 8.8572 mL | |
| 10 mM | 0.1771 mL | 0.8857 mL | 1.7714 mL | 4.4286 mL | |
| 15 mM | 0.1181 mL | 0.5905 mL | 1.1810 mL | 2.9524 mL | |
| 20 mM | 0.0886 mL | 0.4429 mL | 0.8857 mL | 2.2143 mL | |
| 25 mM | 0.0709 mL | 0.3543 mL | 0.7086 mL | 1.7714 mL | |
| 30 mM | 0.0590 mL | 0.2952 mL | 0.5905 mL | 1.4762 mL | |
| 40 mM | 0.0443 mL | 0.2214 mL | 0.4429 mL | 1.1072 mL | |
| 50 mM | 0.0354 mL | 0.1771 mL | 0.3543 mL | 0.8857 mL | |
| 60 mM | 0.0295 mL | 0.1476 mL | 0.2952 mL | 0.7381 mL | |
| 80 mM | 0.0221 mL | 0.1107 mL | 0.2214 mL | 0.5536 mL | |
| 100 mM | 0.0177 mL | 0.0886 mL | 0.1771 mL | 0.4429 mL |
Fentonium bromide Related Classifications
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