Flusulfamide
Flusulfamide is a sulfonanilide Fungicide that effectively inhibits the germination of resting spores of Plasmodiophora brassicae, the pathogen causing clubroot in cruciferous crops. Flusulfamide blocks the developmental process of resting spores from stage 1 to stage 2. By downregulating germination-related genes and upregulating immunophilin genes (such as PbCyp3), it induces abnormal accumulation of the PbCYP3 protein, thereby causing the spores to deplete energy in a state of continuous energy consumption without germination, and reducing their infectivity. Flusulfamide reduces soil ATP content in the early stage of application, but soil microbial biomass gradually recovers 3 days later. Flusulfamide is widely used in research on clubroot control.
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- CAS No.: 106917-52-6
- 화학식: C13H7Cl2F3N2O4S
- 분자량:415.17
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Flusulfamide (1 ppm; 3-6 d) inhibits the progression of primary zoospore development from stage 1 to stages 2 and 3 in resting spores of Plasmodiophora brassicae (Williams race 4) on the 3rd and 6th days post-incubation[3].
Flusulfamide (0.5-2 ppm; 5 d) downregulates 80% of the repeatedly expressed germination-related genes in resting spores of Plasmodiophora brassicae (Williams pathotype 4)[3].
Flusulfamide (1 ppm; 24 h) significantly upregulates the expression of most immunophilin genes in resting spores of Plasmodiophora brassicae (Williams pathotype 4), among which PbCYP3, PbCYP8 and PbCYP10 show upregulated expression at multiple early time points up to 24 h[3].
Flusulfamide (1 ppm; 24 h) increases the accumulation of the 17.5 kDa PbCYP3 protein in resting spores of Plasmodiophora brassicae (Williams’ race 4)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 106917-52-6
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Appearance Solid
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분자량 415.17
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화학식 C13H7Cl2F3N2O4S
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Color Light yellow to yellow
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SMILES
O=S(NC(C(Cl)=C1)=CC=C1[N+]([O-])=O)(C2=CC=C(C(C(F)(F)F)=C2)Cl)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (120.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (285 KB)
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SDS (564 KB)
- English - EN (564 KB)
- Français - FR (564 KB)
- Deutsch - DE (564 KB)
- Norwegian - NO (564 KB)
- Español - ES (564 KB)
- Swedish - SV (564 KB)
- Italian - IT (564 KB)
- Korean - KR (564 KB)
- Portuguese - PT (564 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4087 mL | 12.0433 mL | 24.0865 mL | 60.2163 mL |
| 5 mM | 0.4817 mL | 2.4087 mL | 4.8173 mL | 12.0433 mL | |
| 10 mM | 0.2409 mL | 1.2043 mL | 2.4087 mL | 6.0216 mL | |
| 15 mM | 0.1606 mL | 0.8029 mL | 1.6058 mL | 4.0144 mL | |
| 20 mM | 0.1204 mL | 0.6022 mL | 1.2043 mL | 3.0108 mL | |
| 25 mM | 0.0963 mL | 0.4817 mL | 0.9635 mL | 2.4087 mL | |
| 30 mM | 0.0803 mL | 0.4014 mL | 0.8029 mL | 2.0072 mL | |
| 40 mM | 0.0602 mL | 0.3011 mL | 0.6022 mL | 1.5054 mL | |
| 50 mM | 0.0482 mL | 0.2409 mL | 0.4817 mL | 1.2043 mL | |
| 60 mM | 0.0401 mL | 0.2007 mL | 0.4014 mL | 1.0036 mL | |
| 80 mM | 0.0301 mL | 0.1505 mL | 0.3011 mL | 0.7527 mL | |
| 100 mM | 0.0241 mL | 0.1204 mL | 0.2409 mL | 0.6022 mL |
Flusulfamide Related Classifications
HY-121628 Related Classifications
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