Cat. No.: HY-147082

GA-017

7 Cited Publications

고객리뷰

Based on 7 publication(s) in Google Scholar

GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.95%
CAS No.: 2351906-74-4
화학식: C₁₈H₂₁N₃O₄
분자량:343.38

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

GA-017 Chemical Structure

CAS No.: 2351906-74-4

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Sample (0.1mg)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (7)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Lats1

Lats2

YAP/TAZ

All YAP Isoforms :

In Vitro

GA-017 suppresses the cell death of HUVECs and promotes their cell growth^[1].
GA-017 facilitates SKOV3 cell growth, with an EC₅₀ of 3.51 ± 0.26 μM^[1].
GA-017 competitively inhibited LATS1 and 2 against ATP, with K_i (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2351906-74-4
Appearance Solid
분자량 343.38
화학식 C₁₈H₂₁N₃O₄
Color Off-white to light yellow
SMILES

O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (7)

All RT-PCRWBCell Migration/Invasion Assay

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Journal Impact Factor

Mol Cell

Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. [Abstract]

2024 Aug 18:S1097-2765(24)00633-6. PMID: 39173637

GA-017 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Aug 18:S1097-2765(24)00633-6. [Abstract]

Caspase-1 (p20) and gasdermin D (cleaved N-term) processing upon NLRP3 inflammasome in BMDM cells with or without the treatment of TRULI and GA-017 (10 μM, 5h) .
Cell Rep Med

A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma. [Abstract]

2026 Feb 17;7(2):102622. PMID: 41707653
Cell Death Dis

Generation of proliferative hESC-derived grape-clustered hepatocyte organoids with multipolar architecture as regenerative counterpart via synergy of YAP and IGF2 pathways. [Abstract]

2026 Mar 26;17(1):381. PMID: 41888105
Int Immunopharmacol

ACTL6A accelerates the progression of NSCLC through hippo/YAP signaling axis and TAMs-mediated immune regulation. [Abstract]

2026 Jan 1;168(Pt 1):115828. PMID: 41223612

GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]

ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) and K-975 for 24 h. Then, qRT-PCR was used to detect the expression of TEAD1 and TEAD4.

GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]

GA-017 (10 μM) for 24 h. Wound healing assay (scale bar =100 μm) was performed to detect the changes of NCI-H520 cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.

GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]

GA-017 (10 μM) for 24 h. Transwell assay (scale bar =50 μm) was performed to detect the changes of cell migration. *P < 0.05, **P < 0.01 and ***P < 0.001.

GA-017 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2026 Jan 1;168(Pt 1):115828. [Abstract]

ACTL6A-interfered NCI-H520 cells were treated with GA-017 (10 μM) for 24 h or K-975. Then, qRT-PCR was performed to detect the expression of CSF1.
Cancer Biother Radiopharm

Dihydroartemisinin Inhibits Epithelial-Mesenchymal Transition Progression in Medullary Thyroid Carcinoma Through the Hippo Signaling Pathway Regulated by Interleukin-6. [Abstract]

2025 Mar;40(2):139-150 PMID: 39286872
bioRxiv

2025 April 14.
SSRN

2025 Jan 3.

용액&용해도

In Vitro:

DMSO : 20.83 mg/mL (60.66 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9122 mL

14.5611 mL

29.1223 mL

5 mM

0.5824 mL

2.9122 mL

5.8245 mL

10 mM

0.2912 mL

1.4561 mL

2.9122 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298(4):101779. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9122 mL	14.5611 mL	29.1223 mL	72.8056 mL
	5 mM	0.5824 mL	2.9122 mL	5.8245 mL	14.5611 mL
	10 mM	0.2912 mL	1.4561 mL	2.9122 mL	7.2806 mL
	15 mM	0.1941 mL	0.9707 mL	1.9415 mL	4.8537 mL
	20 mM	0.1456 mL	0.7281 mL	1.4561 mL	3.6403 mL
	25 mM	0.1165 mL	0.5824 mL	1.1649 mL	2.9122 mL
	30 mM	0.0971 mL	0.4854 mL	0.9707 mL	2.4269 mL
	40 mM	0.0728 mL	0.3640 mL	0.7281 mL	1.8201 mL
	50 mM	0.0582 mL	0.2912 mL	0.5824 mL	1.4561 mL
	60 mM	0.0485 mL	0.2427 mL	0.4854 mL	1.2134 mL

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GA-017

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Transcription Factor-Targeted Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) GA-017

All YAP Isoforms

Biological Activity

Chemical Information

Publications (7)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

GA-017

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Transcription Factor-Targeted Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Multi-Target Compound Library

Bioactive Compound Library Max

Bioactive Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) GA-017

All YAP Isoforms

Biological Activity

Chemical Information

Publications (7)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

GA-017 Related Classifications

Cat. No.: HY-147082