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Cat. No.: HY-183582

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GB1841

GB1841 is an orally active and selective galectin inhibitor with human galectin-1 K_d of 0.027 μM, human galectin-3 K_d of 0.14 μM, mouse galectin-1 K_d of 0.034 μM and mouse galectin-3 K_d of 1.170 μM. GB1841 can be used for the research of lung cancer.

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CAS No.: 2573135-33-6
화학식: C₁₈H₁₆BrClN₆O₄S₂
분자량:559.84

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

GB1841 Chemical Structure

CAS No.: 2573135-33-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

Galectin-1

0.027 μM (Kd)

Galectin-3

0.14 μM (Kd)

All Galectin Isoforms :

In Vitro

GB1841 potently binds human galectin-1 (K_d 0.027 μM), human galectin-3 (K_d 0.14 μM), and human galectin-4C (K_d 0.25 μM); it also ^[1].
GB1841 potently binds mouse galectin-1 (K_d 0.034 μM) and mouse galectin-3 (K_d 1.170 μM)^[1].
GB1841 reduces A549 human lung adenocarcinoma cell viability by 62% at 90 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

GB1841 (30 mg/kg; p.o.; b.i.d. for 3 days) achieves free plasma levels sufficient for mouse galectin-1 inhibition for over 24 h, with a >90-fold therapeutic window relative to cell toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (female, 17−19 g, syngeneic implantation of LL/2 lung cancer cells)^[1]
Dosage:

30 mg/kg
Administration:

p.o.; b.i.d. for 3 days
Result:

Achieved free plasma Cmax levels of 1 μM.
Remained above the mouse galectin-1 K_d (0.034 μM) for over 24 h.
Did not reach levels above the mouse galectin-3 K_d (1.170 μM).
Demonstrated a >90-fold therapeutic window compared to cell toxicity levels (62% viability reduction at 90 μM in A549 cells).

Chemical Information

CAS No. 2573135-33-6
분자량 559.84
화학식 C₁₈H₁₆BrClN₆O₄S₂
SMILES

O[C@@H]1[C@H](N2C=C(C3=NC(Cl)=CS3)N=N2)[C@@H](OC)[C@@H](SC4=C(C#N)N=CC(Br)=C4)O[C@@H]1CO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zetterberg FR, et al. An Orally Available Halothiazole Glycomimetic as a Cancer-Targeting Dual Galectin-1 and Galectin-3 Inhibitor. J Med Chem. 2026;69(9):10494-10514. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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