NR1H3 - nuclear receptor subfamily 1 group H member 3 Gene

Also Known as LXRA; LXR-a; RLD-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10062

About NR1H3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,248,300-47,269,033 (from NCBI)

This gene has 35 transcripts (splice variants), 392 orthologues and 18 paralogues. Ubiquitous expression in fat (RPKM 25.1), spleen (RPKM 16.7) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the NR1 subfamily of the Nuclear Receptor Superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of Cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NR1H3 Products (6)

mRNA	Protein	Name
NM_001130101.3	NP_001123573.1	oxysterols receptor LXR-alpha isoform 2
NM_001130102.3	NP_001123574.1	oxysterols receptor LXR-alpha isoform 3
NM_001251934.2	NP_001238863.1	oxysterols receptor LXR-alpha isoform 4
NM_001251935.2	NP_001238864.1	oxysterols receptor LXR-alpha isoform 4
NM_001363595.2	NP_001350524.1	oxysterols receptor LXR-alpha isoform 5
NM_005693.4	NP_005684.2	oxysterols receptor LXR-alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	19481530	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12040021	GOA
enables sterol response element binding	IDA IDA: Inferred from direct assay	19628791	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18511497	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19229075	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	19628791	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18511497	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	18511497	GOA
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	7744246	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7744246	GOA
involved in negative regulation of cholesterol storage	IMP IMP: Inferred from mutant phenotype	17693624	GOA
involved in negative regulation of lipid transport	IMP IMP: Inferred from mutant phenotype	17693624	GOA
involved in negative regulation of pinocytosis	IMP IMP: Inferred from mutant phenotype	17693624	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	25661920	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19628791	GOA
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	16141411	GOA
involved in positive regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	17186944	GOA
involved in positive regulation of cholesterol transport	IDA IDA: Inferred from direct assay	16141411	GOA
involved in positive regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	17186944	GOA
involved in positive regulation of lipid biosynthetic process	IDA IDA: Inferred from direct assay	23499676	GOA
involved in positive regulation of lipoprotein lipase activity	IMP IMP: Inferred from mutant phenotype	17186944	GOA
involved in positive regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	17186944	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	18511497	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7744246	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17186944	GOA
involved in positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	17693624	GOA
involved in response to progesterone	IDA IDA: Inferred from direct assay	16141411	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	19167885	GOA
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	18511497	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	25416956	GOA
located in chromatin	IDA IDA: Inferred from direct assay	18511497	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25661920	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	18511497	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR1H3 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
447 a.a.

Protein Preferred Names	Protein Names
oxysterols receptor LXR-alpha

NR1H3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NR1H3	Q13133	PPARA	Homo sapiens	Q07869-1	SPR	15722453
Intra	NR1H3	Q13133	NCOR1	Homo sapiens	O75376	FRET	26120082
Intra	NR1H3	Q13133	NCOR1	Homo sapiens	O75376	Anti Tag CoIP	33961781
Intra	NR1H3	Q13133	SUV39H1	Homo sapiens	O43463	Y2H	23455924
Intra	NR1H3	Q13133	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
Intra	NR1H3	Q13133	NCOA1	Homo sapiens	Q15788	Anti Bait CoIP	25962847
Intra	NR1H3	Q13133	NCOA1	Homo sapiens	Q15788	Pull Down	20682316
Intra	NR1H3	Q13133	PPARD	Homo sapiens	Q03181	SPR	15722453
Intra	NR1H3	Q13133	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	NR1H3	Q13133	RXRG	Homo sapiens	P48443	Y2H Array	31515488
Intra	NR1H3	Q13133	RXRG	Homo sapiens	P48443	Validated Y2H	25416956
Intra	NR1H3	Q13133	RXRG	Homo sapiens	P48443	Y2H Array	25416956
Intra	NR1H3	Q13133	RXRG	Homo sapiens	P48443	Y2H Prey Pooling	25416956
Intra	NR1H3	Q13133	RXRG	Homo sapiens	P48443	Y2H	21516116
Intra	NR1H3	Q13133	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	NR1H3	Q13133	RXRB	Homo sapiens	P28702	Y2H Prey Pooling	25416956
Intra	NR1H3	Q13133	RXRB	Homo sapiens	P28702	Validated Y2H	25416956
Intra	NR1H3	Q13133	RXRB	Homo sapiens	P28702	Anti Tag CoIP	33961781
Intra	NR1H3	Q13133	PPARG	Homo sapiens	P37231	SPR	15722453
Intra	NR1H3	Q13133	RXRA	Homo sapiens	P19793	Pull Down	20682316

Cross: Cross-species interaction Intra: Intraspecies interaction

NR1H3 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P80423	LXR alpha Antibody (YA305)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Cerebrotendinous Xanthomatosis	CTX Cerebral Cholesterinosis Cholestanol Storage Disease Xanthomatosis, Cerebrotendinous Sterol 27-Hydroxylase Deficiency Xanthomatosis Cerebrotendinous Cerebrotendinous Cholesterinosis Cholestanolosis Van Bogaert-Scherer-Epstein Disease
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Pulmonary Alveolar Proteinosis
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS22684	Nr1h3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09530	NR1H3 Human Pre-designed siRNA Set A		/	Unkown
HY-180863	NR1H3 modulator-1		/	Unkown
HY-RS29198	Nr1h3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NR1H3	RGD	RGD:61909
Bos taurus	NR1H3	VGNC	VGNC:32231
Canis familiaris	NR1H3	VGNC	VGNC:43943
Macaca mulatta	NR1H3	VGNC	VGNC:75505
Felis catus	NR1H3	VGNC	VGNC:68545
Mus musculus	NR1H3	MGD	MGI:1352462
Others	NR1H3	NCBI