PIAS3 - protein inhibitor of activated STAT 3 Gene

Also Known as ZMIZ5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10401

About PIAS3

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,848,522-145,859,081 (from NCBI)

This gene has 9 transcripts (splice variants), 128 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 17.3), skin (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 Ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

PIAS3 Products (1)

mRNA Protein Name
NM_006099.3 NP_006090.2 E3 SUMO-protein ligase PIAS3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
15507434 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11060035 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein sumoylation IDA
IDA: Inferred from direct assay
24651376 GOA
involved in positive regulation of protein sumoylation IDA
IDA: Inferred from direct assay
17696781 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIAS3 Protein Structure

PINIT

PINIT: PINIT domain (122 - 278)

zf-MIZ

zf-MIZ: MIZ/SP-RING zinc finger (323 - 371)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 628 a.a.
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS3

  • E3 SUMO-protein transferase PIAS3

PIAS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIAS3 Q9Y6X2 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
Intra
PIAS3 Q9Y6X2 PRKCA Homo sapiens P17252
Validated Y2H
32814053
Intra
PIAS3 Q9Y6X2 PRKCA Homo sapiens P17252
Y2H Array
32814053
Intra
PIAS3 Q9Y6X2 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
PIAS3 Q9Y6X2 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
PIAS3 Q9Y6X2 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
PIAS3 Q9Y6X2 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
PIAS3 Q9Y6X2 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
PIAS3 Q9Y6X2 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
PIAS3 Q9Y6X2 PLIN3 Homo sapiens O60664
Y2H Array
32296183
Intra
PIAS3 Q9Y6X2 PLIN3 Homo sapiens O60664
Y2H Prey Pooling
32296183
Intra
PIAS3 Q9Y6X2 MBD1 Homo sapiens Q9UIS9
Pull Down
17066076
Intra
PIAS3 Q9Y6X2 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
PIAS3 Q9Y6X2 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
PIAS3 Q9Y6X2 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

PIAS3 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P810969 PIAS3 Antibody WB, IHC-P Human, Mouse, Rat
HY-P82730 PIAS1/2 Antibody (YA2475) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Unilateral Focal Polymicrogyria
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS10475 PIAS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21688 Pias3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28206 Pias3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PIAS3 MGD MGI:1913126
Macaca mulatta PIAS3 VGNC VGNC:75811
Rattus norvegicus PIAS3 RGD RGD:708413
Bos taurus PIAS3 VGNC VGNC:32857
Felis catus PIAS3 VGNC VGNC:64160
Canis familiaris PIAS3 VGNC VGNC:44521
Others PIAS3 NCBI