RGMA - repulsive guidance molecule BMP co-receptor a Gene

Also Known as RGM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56963

About RGMA

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:93,035,271-93,089,211 (from NCBI)

This gene has 13 transcripts (splice variants), 203 orthologues and 2 paralogues. Biased expression in brain (RPKM 32.8), endometrium (RPKM 14.6) and 13 other tissues.

Summary

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RGMA Products (6)

mRNA	Protein	Name
NM_001166283.2	NP_001159755.1	repulsive guidance molecule A isoform 1
NM_001166286.2	NP_001159758.1	repulsive guidance molecule A isoform 2 precursor
NM_001166287.2	NP_001159759.1	repulsive guidance molecule A isoform 2 precursor
NM_001166288.2	NP_001159760.1	repulsive guidance molecule A isoform 2 precursor
NM_001166289.2	NP_001159761.1	repulsive guidance molecule A isoform 2 precursor
NM_020211.3	NP_064596.2	repulsive guidance molecule A isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables transferrin receptor binding	IPI IPI: Inferred from physical interaction	22728873	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22728873	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGMA Protein Structure

RGM_N

RGM_C

0
100
200
300
400
450 a.a.

Protein Preferred Names	Protein Names
repulsive guidance molecule A	RGM domain family, member A

RGMA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RGMA	Q96B86	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	RGMA	Q96B86	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RGMA Proteins

Cat. No.	상품명	Accession	Purity
HY-P76572	RGMA Protein, Human (HEK293, His)	Q96B86-1 (C48-G422)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78197	RGMA Protein, Human (Biotinylated, HEK293, His-Avi)	Q96B86-1 (C48-G422)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78508	RGMA Protein, Human (HEK293, His-Avi)	Q96B86-1 (C48-G422)	≥ 95%, as determined by Bis-Tris PAGE.

RGMA Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P87260	Repulsive guidance molecule A Antibody (YA6945)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hemochromatosis Type 2	Juvenile Hemochromatosis Juvenile Hereditary Hemochromatosis Hfe2 Jhh Hemochromatosis Juvenile Iron Overload Disease Juvenile Hemochromatosis, Juvenile Hemochromatosis, Type 2 Hemochromatosis Hemochromatosis, Type 1
Intracranial Hypertension	Raised Intracranial Pressure
Amusia	Receptive Amusia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	상품명	효과	Purity	Phase
HY-P99359	Elezanumab	Inhibitor	99.91%	Phase 2
HY-P99959	Unasnemab		99.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS11894	RGMA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18785	Rgma Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25274	Rgma Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RGMA	RGD	RGD:1311983
Bos taurus	RGMA	VGNC	VGNC:33906
Felis catus	RGMA	VGNC	VGNC:64592
Macaca mulatta	RGMA	VGNC	VGNC:76870
Mus musculus	RGMA	MGD	MGI:2679262
Canis familiaris	RGMA	VGNC	VGNC:45515
Others	RGMA	NCBI