TRPC5 - transient receptor potential cation channel subfamily C member 5 Gene

Also Known as TRP5; PPP1R159

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7224

About TRPC5

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:111,768,011-112,082,776 (from NCBI)

This gene has 1 transcript (splice variant), 228 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including Calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

TRPC5 Products (1)

mRNA Protein Name
NM_012471.3 NP_036603.1 short transient receptor potential channel 5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
20164195 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20164195 GOA
Cellular Component GO Annotation Evidence References Source
part of calcium channel complex IDA
IDA: Inferred from direct assay
20164195 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC5 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (38 - 118)

Ank

Ank: Ankyrin repeat (143 - 164)

TRP_2

TRP_2: Transient receptor ion channel II (176 - 238)

Ion_trans

Ion_trans: Ion transport protein (406 - 624)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 973 a.a.
Protein Preferred Names Protein Names

short transient receptor potential channel 5

  • TRP-5

Related Diseases

Diseases Alias
Pyloric Stenosis
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

  • Olmsted Syndrome

  • Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

  • Palmoplantar And Periorificial Keratoderma

  • Olms
Familial Episodic Pain Syndrome

  • Feps
Pseudohypoaldosteronism
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-17386 Rosiglitazone Modulator 99.94% Yes
HY-17386A Rosiglitazone hydrochloride Modulator 99.81% Yes
HY-17386B Rosiglitazone potassium Modulator 99.13% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명 효과
Purity Phase
HY-162584 TRPC5-IN-6 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-133168 Englerin A Activator 99.50% Unkown
HY-12949 ML204 Inhibitor 98.45% Unkown
HY-12949A ML204 hydrochloride Inhibitor 99.74% Unkown
HY-172106 TRPC5-IN-5 Inhibitor / Unkown
HY-144429 TRPC5-IN-4 Inhibitor / Unkown
HY-173024 TRPC4/5-IN-3 Inhibitor 99.65% Unkown
HY-146155 TRPC4/5-IN-1 Inhibitor / Unkown
HY-162090 TRPC antagonist 1 Antagonist / Unkown
HY-184164 JD03-02 Antagonist / Unkown
HY-18101 BD-1063 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRPC5 VGNC VGNC:66585
Rattus norvegicus TRPC5 RGD RGD:619787
Bos taurus TRPC5 VGNC VGNC:36385
Canis familiaris TRPC5 VGNC VGNC:47870
Mus musculus TRPC5 MGD MGI:109524
Macaca mulatta TRPC5 VGNC VGNC:78653
Others TRPC5 NCBI