CDH1 - cadherin 1 Gene
Also Known as UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324
Species: Homo sapiens
About CDH1
This gene has 11 transcripts (splice variants), 146 orthologues, 33 paralogues and is associated with 144 phenotypes. Broad expression in thyroid (RPKM 81.8), colon (RPKM 70.0) and 17 other tissues.
Summary
This gene encodes a classical Cadherin of the Cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular Cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian Cancer. Loss of function of this gene is thought to contribute to Cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates Bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with Other members of the Cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
CDH1 Products (8)
| mRNA | Protein | Name |
|---|---|---|
| NM_001317184.2 | NP_001304113.1 | cadherin-1 isoform 2 precursor |
| NM_001317185.2 | NP_001304114.1 | cadherin-1 isoform 3 |
| NM_001317186.2 | NP_001304115.1 | cadherin-1 isoform 4 |
| NM_004360.5 | NP_004351.1 | cadherin-1 isoform 1 preproprotein |
| NM_001317184.2 | NP_001304113.1 | cadherin-1 isoform 2 precursor |
| NM_001317185.2 | NP_001304114.1 | cadherin-1 isoform 3 |
| NM_001317186.2 | NP_001304115.1 | cadherin-1 isoform 4 |
| NM_004360.5 | NP_004351.1 | cadherin-1 isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables GTPase activating protein binding |
IPI
IPI: Inferred from physical interaction
|
20116244 | GOA |
| enables ankyrin binding |
IPI
IPI: Inferred from physical interaction
|
17620337 | GOA |
| enables beta-catenin binding |
IDA
IDA: Inferred from direct assay
|
17620337 | GOA |
| enables cell adhesion molecule binding |
IPI
IPI: Inferred from physical interaction
|
21724833 | GOA |
| enables gamma-catenin binding |
IPI
IPI: Inferred from physical interaction
|
1639850 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
19114658 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10725230 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in actin cytoskeleton |
IDA
IDA: Inferred from direct assay
|
16338932 | GOA |
| located in adherens junction |
IDA
IDA: Inferred from direct assay
|
16338932 | GOA |
| located in apical junction complex |
IDA
IDA: Inferred from direct assay
|
10460003 | GOA |
| part of catenin complex |
IDA
IDA: Inferred from direct assay
|
18593713 | GOA |
| located in cell junction |
IDA
IDA: Inferred from direct assay
|
19038973 | GOA |
| colocalizes with cortical actin cytoskeleton |
IDA
IDA: Inferred from direct assay
|
24046456 | GOA |
| located in cytoplasmic side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
20189993 | GOA |
| part of flotillin complex |
IDA
IDA: Inferred from direct assay
|
24046456 | GOA |
| located in lamellipodium |
IDA
IDA: Inferred from direct assay
|
24046456 | GOA |
| located in lateral plasma membrane |
IDA
IDA: Inferred from direct assay
|
16338932 | GOA |
| located in membrane |
IDA
IDA: Inferred from direct assay
|
16338932 | GOA |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
16338932 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
20859650 | GOA |
| located in trans-Golgi network |
IMP
IMP: Inferred from mutant phenotype
|
17620337 | GOA |
CDH1 Protein Structure
Cadherin_pro: Cadherin prodomain like (27 - 115)
Cadherin: Cadherin domain (161 - 253)
Cadherin: Cadherin domain (268 - 366)
Cadherin: Cadherin domain (380 - 478)
Cadherin: Cadherin domain (493 - 581)
Cadherin: Cadherin domain (600 - 686)
Cadherin_C: Cadherin cytoplasmic region (740 - 878)
- 0
- 200
- 400
- 600
- 800
- 882 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cadherin-1 |
|
CDH1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CDH1 | P12830 | FGFR1 | Homo sapiens | P11362 | 25241761 | |
|
Intra
|
CDH1 | P12830 | FGFR1 | Homo sapiens | P11362 | 11401320 | |
|
Intra
|
CDH1 | P12830 | ECT2 | Homo sapiens | Q9H8V3 | 22750944 | |
|
Intra
|
CDH1 | P12830 | HUWE1 | Homo sapiens | Q7Z6Z7-2 | 32814053 | |
|
Intra
|
CDH1 | P12830 | HUWE1 | Homo sapiens | Q7Z6Z7-2 | 32814053 | |
|
Intra
|
CDH1 | P12830 | HUWE1 | Homo sapiens | Q7Z6Z7-2 | 32814053 | |
|
Intra
|
CDH1 | P12830 | PRKD1 | Homo sapiens | Q15139 | 15695390 | |
|
Intra
|
CDH1 | P12830 | PRKD1 | Homo sapiens | Q15139 | 15695390 | |
|
Intra
|
CDH1 | P12830 | PRKD1 | Homo sapiens | Q15139 | 15695390 | |
|
Intra
|
CDH1 | P12830 | TNS3 | Homo sapiens | Q68CZ2 | 19732724 | |
|
Intra
|
CDH1 | P12830 | MGC39372 | Homo sapiens | Q8TB02 | 32814053 | |
|
Intra
|
CDH1 | P12830 | MGC39372 | Homo sapiens | Q8TB02 | 32814053 | |
|
Intra
|
CDH1 | P12830 | MGC39372 | Homo sapiens | Q8TB02 | 32814053 | |
|
Intra
|
CDH1 | P12830 | EGFR | Homo sapiens | P00533 | 24658140 | |
|
Intra
|
CDH1 | P12830 | EGFR | Homo sapiens | P00533 | 25241761 | |
|
Intra
|
CDH1 | P12830 | PPP1CA | Homo sapiens | P62136 | 17274640 | |
|
Intra
|
CDH1 | P12830 | PPP1CA | Homo sapiens | P62136 | 17274640 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 16212417 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 18593713 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 17237808 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 17220478 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 12640114 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 34591612 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 19016843 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 24424122 | |
|
Intra
|
CDH1 | P12830 | CTNNB1 | Homo sapiens | P35222 | 16212417 | |
|
Intra
|
CDH1 | P12830 | CTNNA1 | Homo sapiens | P35221 | 34591612 | |
|
Intra
|
CDH1 | P12830 | CTNNA1 | Homo sapiens | P35221 | 16212417 | |
|
Intra
|
CDH1 | P12830 | CTNNA1 | Homo sapiens | P35221 | 19016843 | |
|
Intra
|
CDH1 | P12830 | CTNNA1 | Homo sapiens | P35221 | 16212417 | |
|
Intra
|
CDH1 | P12830 | CTNNA1 | Homo sapiens | P35221 | 22750944 | |
|
Intra
|
CDH1 | P12830 | CDH1 | Homo sapiens | P12830 | 19114658 | |
|
Intra
|
CDH1 | P12830 | CDH1 | Homo sapiens | P12830 | 19114658 | |
|
Intra
|
CDH1 | P12830 | CDC27 | Homo sapiens | P30260 | 20951947 | |
|
Cross
|
CDH1 | P12830 | inlA | Listeria monocytogenes serovar 1/2a | P0DJM0 | 12526809 |
Recombinant CDH1 Proteins
| Cat. No. | 상품명 | Accession | Purity |
|---|---|---|---|
| HY-P7697 | Cadherin-1/CD324 Protein, Human (HEK293, His) | P12830-1 (D155-I707) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74370 | Cadherin-1/CD324 Protein, Human (HEK293, Fc) | P12830-1 (Q23-I707) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77518 | Cadherin-1/CD324 Protein, Human (Biotinylated, HEK293, Fc) | P12830-1 (Q23-I707) | ≥ 90%, as determined by reducing SDS-PAGE. |
CDH1 Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P80112 | E-Cadherin Antibody (YA778) | WB, IHC-P | Human, Mouse |
| HY-P80113 | E-Cadherin Antibody (YA470) | WB, ICC/IF, IHC-P, FC, IP | Human |
| HY-P81271 | E-Cadherin Antibody | WB, IHC-P, IHC-F, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P82834 | Phospho-E-Cadherin (Ser838/Ser840) Antibody (YA2579) | WB, IHC-P, IP | Human, Mouse |
| HY-P82834A | Phospho-E-Cadherin (Ser838/Ser840) Antibody (YA2579)(PBS only) | WB, IHC-P, IP | Human, Mouse |
| HY-P84078 | E-Cadherin Antibody (YA3775) | WB, IHC-P, FC, ELISA | Human, Mouse, Monkey |
| HY-P84078A | E-Cadherin Antibody (YA3775)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse, Monkey |
| HY-P85836 | Cadherin Antibody (YA5528) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86027 | Cadherin Antibody (YA5719) | IHC-P, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Blepharocheilodontic Syndrome 1 |
|
|
| Diffuse Gastric And Lobular Breast Cancer Syndrome |
|
|
| Diffuse Gastric Cancer |
|
|
| Endometrial Cancer |
|
|
| Prostate Cancer |
|
|
| Ovarian Cancer |
|
|
| Breast Lobular Carcinoma |
|
|
| Breast Cancer |
|
|
| Bap1 Tumor Predisposition Syndrome |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Colorectal Cancer |
|
|
| Cleft Lip With Or Without Cleft Palate |
|
|
| Hereditary Breast Cancer |
|
|
| Breast Ductal Carcinoma |
|
|
| Goblet Cell Carcinoid |
|
|
| Tongue Carcinoma |
|
|
| Signet Ring Cell Adenocarcinoma |
|
|
| Renal Fibrosis |
|
|
| Cleft Lip/Palate |
|
|
| Adenocarcinoma |
|
|
| Euryblepharon |
|
|
| Familial Adenomatous Polyposis |
|
|
| Transitional Cell Carcinoma |
|
|
| Oral Submucous Fibrosis |
|
|
| Gastric Cancer |
|
|
| Microinvasive Gastric Cancer |
|
|
| Bladder Cancer |
|
|
| Inflammatory Breast Carcinoma |
|
|
| Colon Adenocarcinoma |
|
|
| Distichiasis |
|
|
| Tubular Adenocarcinoma |
|
|
| Cleft Lip |
|
|
| Pulmonary Sclerosing Hemangioma |
|
|
| Malignant Pleural Mesothelioma |
|
|
| Laryngeal Squamous Cell Carcinoma |
|
|
| Tooth Agenesis |
|
|
| Squamous Cell Carcinoma |
|
|
| Neuroendocrine Carcinoma |
|
|
| Adenoid Cystic Carcinoma |
|
|
| Placenta Accreta |
|
|
| Papillary Carcinoma |
|
|
| Bile Duct Cancer |
|
|
| Gastric Diffuse Adenocarcinoma |
|
|
| Bilateral Breast Cancer |
|
|
| Pemphigus Vulgaris, Familial |
|
|
| Adenoma |
|
|
| Cholecystitis |
|
|
| Germinoma |
|
|
| Gastric Adenocarcinoma |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Bronchiolo-Alveolar Adenocarcinoma |
|
|
| Pancreatic Cancer |
|
|
| Adenoid Squamous Cell Carcinoma |
|
|
| Carcinosarcoma |
|
|
| Pseudomyxoma Peritonei |
|
|
| Cervical Squamous Cell Carcinoma |
|
|
| Lobular Neoplasia |
|
|
| Pelvic Inflammatory Disease |
|
|
| Keratoacanthoma |
|
|
| Hepatocellular Adenoma |
|
|
| Ovarian Stromal Hyperthecosis |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Mucoepidermoid Carcinoma |
|
|
| Linitis Plastica |
|
|
| Gallbladder Cancer |
|
|
| Gastroenteritis |
|
|
| Sarcoma, Synovial |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Cystitis |
|
|
| Lung Cancer |
|
|
| Ectropion |
|
|
| Teratoma |
|
|
| Esophageal Cancer |
|
|
| Breast Carcinoma In Situ |
|
|
| Urolithiasis |
|
|
| Pre-Malignant Neoplasm |
|
|
| Melanoma |
|
|
| Gastritis |
|
|
| Follicular Adenoma |
|
|
| Cholangiocarcinoma |
|
|
| Chordoma |
|
|
| Mesothelioma, Malignant |
|
|
| In Situ Carcinoma |
|
|
| Neuroendocrine Tumor |
|
|
| Penis Basal Cell Carcinoma |
|
|
| Scirrhous Adenocarcinoma |
|
|
| Papilloma |
|
|
| Bladder Urothelial Carcinoma |
|
|
| Prolactinoma |
|
|
| Penile Cancer |
|
|
| Ureteral Disease |
|
|
| Hepatocellular Carcinoma |
|
|
| Ductal Carcinoma In Situ |
|
|
| Gastric Signet Ring Cell Adenocarcinoma |
|
|
| Basal Cell Carcinoma |
|
|
| Esophagus Verrucous Carcinoma |
|
|
| Urethral Syndrome |
|
|
| Thyroid Gland Cancer |
|
|
| Skin Carcinoma |
|
|
| Urinary Tract Obstruction |
|
|
| Hypopharynx Cancer |
|
|
| Glioblastoma |
|
|
| Hepatoblastoma |
|
|
| Diarrhea |
|
|
| Hemangioma |
|
|
| Tonsil Cancer |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Ectodermal Dysplasia |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Breast Benign Neoplasm |
|
|
| Sarcomatoid Transitional Cell Carcinoma |
|
|
| Thoracic Benign Neoplasm |
|
|
| Keratinizing Squamous Cell Carcinoma |
|
|
| Oropharynx Cancer |
|
|
| Renal Pelvis Adenocarcinoma |
|
|
| Corneal Dystrophy, Posterior Polymorphous, 4 |
|
|
| Lip And Oral Cavity Cancer |
|
|
| Mixed Cell Type Cancer |
|
|
| Arthrogryposis, Renal Dysfunction, And Cholestasis 1 |
|
|
| Verrucous Carcinoma |
|
|
| Colon Adenoma |
|
|
| Intestinal Benign Neoplasm |
|
|
| Listeriosis |
|
|
| Colorectal Adenocarcinoma |
|
|
| Estrogen-Receptor Negative Breast Cancer |
|
|
| Colorectal Adenoma |
|
|
| Obstructive Nephropathy |
|
|
| Cerebrovascular Benign Neoplasm |
|
|
| Colonic Benign Neoplasm |
|
|
| Medulloblastoma |
|
|
| Skin Squamous Cell Carcinoma |
|
|
| Papilloma Of Choroid Plexus |
|
|
| Pheochromocytoma |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Breast Adenocarcinoma |
|
|
| Tongue Disease |
|
|
| Gallbladder Signet Ring Cell Adenocarcinoma |
|
|
| Parietal Lobe Neoplasm |
|
|
| Inflammatory Bowel Disease |
|
|
| Esophagus Adenocarcinoma |
|
|
| Serous Cystadenocarcinoma |
|
|
| Thyroid Gland Follicular Carcinoma |
|
|
| Ovary Adenocarcinoma |
|
|
| Lymphangioma |
|
|
| Esophageal Adenosquamous Carcinoma |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Gallbladder Disease |
|
|
| Uterine Body Mixed Cancer |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Malignant Exocrine Pancreas Neoplasm |
|
|
| Ovary Epithelial Cancer |
|
|
| Cataract |
|
|
| Cervix Carcinoma |
|
|
| Neuroblastoma |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Tongue Squamous Cell Carcinoma |
|
|
| Cystic Fibrosis |
|
|
| Head And Neck Cancer |
|
|
| Uterine Corpus Cancer |
|
|
| Lynch Syndrome |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Interstitial Lung Disease 2 |
|
|
| Li-Fraumeni Syndrome |
|
|
| Wilms Tumor 1 |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
| Melanoma, Uveal |
|
|
| Autosomal Dominant Polycystic Kidney Disease |
|
|
| Meningioma, Familial |
|
|
| Orofacial Cleft |
|
|
| Skin Disease |
|
|
| Connective Tissue Disease |
|
|
| Eye Disease |
|
|
| Leukemia, Acute Myeloid |
|
|
| Peripheral Nervous System Disease |
|
|
| Nervous System Disease |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CDH1 | MGD | MGI:88354 |
| Bos taurus | CDH1 | VGNC | VGNC:27090 |
| Canis familiaris | CDH1 | VGNC | VGNC:53314 |
| Rattus norvegicus | CDH1 | RGD | RGD:69279 |
| Macaca mulatta | CDH1 | VGNC | VGNC:70803 |
| Others | CDH1 | NCBI |