GRP75-IN-1
GRP75-IN-1 (Compound 33) is an anti-endometrial cancer (EC) agent. GRP75-IN-1 induces apoptosis in endometrial cancer cells. GRP75-IN-1 hydrochloride reduces mitochondrial Ca2+ levels by targeting GRP75 and disrupting its interaction with IP3R. GRP75-IN-1 inhibits tumor growth in human endometrial cancer xenograft animal models. GRP75-IN-1 can be used for research in endometrial cancer.
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- CAS No.: 2922680-16-6
- 화학식: C27H38N4OS
- 분자량:466.68
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Ishikawa | IC50 |
0.99 μM
Compound: 33
|
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human Ishikawa cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 39082833] |
| KLE | IC50 |
3.18 μM
Compound: 33
|
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
|
[PMID: 39082833] |
Chemical Information
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CAS No. 2922680-16-6
-
분자량 466.68
-
화학식 C27H38N4OS
-
SMILES
CN1CCC2(CCN(CC2)CCCCCN3C4=C(SC5=CC=C(C=C53)OC)C=CC=N4)CC1
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선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)