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Cat. No.: HY-N3480

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Isogosferol

(Synonyms: (+)-Isogospherol; Isogospherol)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2.

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CAS No.: 53319-52-1
화학식: C₁₆H₁₄O₅
분자량:286.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Isogosferol Chemical Structure

CAS No.: 53319-52-1

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- In Vitro
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Biological Activity

제품 설명

In Vitro

Isogosferol (100, 200 µM; 1+16 h) decreases LPS (HY-D1056)-stimulated NO expression in RAW 264.7 cells^[1].
Isogosferol (0, 25, 50, 100, 200 µM; 1+16 h) decreases LPS-stimulated expression of iNOS, COX-2 protein in a dose-dependent manner^[1].
Isogosferol (0, 25, 50, 100, 200 µM; 1+1 h) decreases the LPS-stimulated expression of NF-κB and pERK1/2 in a dose-dependentmanner^[1].
Isogosferol (50, 100, 200 µM µM; 1+16 h) decreases LPS-stimulated release of the pro-inflammatory cytokine, IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

RAW 264.7 cells
Concentration:

100, 200 µM (stimulated with LPS (1 µg/mL))
Incubation Time:

1+16
Result:

Remarkably down-regulated the LPS-stimulated NO expression with an IC₅₀ of 148 μM and shows no effect on cell viability.

Western Blot Analysis^[1]

Cell Line:

0, 25, 50, 100, 200 µM
Concentration:

1+16
Incubation Time:

1+16
Result:

Decreased the expression of iNOS, COX-2 protein in a dose-dependent manner.

Chemical Information

CAS No. 53319-52-1
분자량 286.28
화학식 C₁₆H₁₄O₅
SMILES

CC([C@@H](O)COC1=C(OC=C2)C2=CC(C=C3)=C1OC3=O)=C
Synonyms

(+)-Isogospherol; Isogospherol
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
- Plants
- Umbelliferae
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2023 Jun 15.

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song HY, et al. Anti-Inflammatory Activities of Isogosferol, a Furanocoumarin Isolated from Citrus junos Seed Shells through Bioactivity-Guided Fractionation. Molecules. 2019 Nov 12;24(22):4088. [Content Brief]

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Keywords

Isogosferol

1 Cited Publications

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Isogosferol

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Isogosferol Related Classifications

HY-N3480 Related Classifications