Ivicentamab
Based on 1 Customer Validation
Ivicentamab (GEN-3009) is a bispecific antibody targeting CD37 with dual epitopes. Ivicentamab carries an E430G mutation in the Fc region, which efficiently promotes IgG hexamer formation on the surface of target cells. Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody, enabling it to exert complement-dependent cytotoxicity in Daudi lymphoma cells. Ivicentamab is mainly used in lymphoma-related research.
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- Purity: 99.82%
- CAS No.: 2364496-42-2
- 분자량:144.88 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
CD37
Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody that promotes on-target IgG hexamerization and enhances complement-dependent cytotoxicity in Daudi lymphoma cells[1].
Ivicentamab-derived biparatopic bispecific anti-CD37 antibody (0.0–1.0 μg/mL) enhances complement-dependent cytotoxicity in Daudi lymphoma cells and mediates potent target cell lysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized CD37 Protein, Human (HEK293, Fc, HY-P77886) can bind Ivicentamab. The EC50 for this effect is 7.22 ng/mL.
Chemical Information
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CAS No. 2364496-42-2
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Appearance Liquid
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분자량 144.88 kDa
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Color Colorless to light yellow
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SMILES
[Ivicentamab]
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Synonyms
GEN-3009
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)