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United States

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Cat. No.: HY-149713

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J1-1

J1-1 is an inhibitor of ICMT with an IC₅₀ of 1.0 μM and has anticancer activity.

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CAS No.: 1244769-10-5
화학식: C₂₅H₃₂N₂O
분자량:376.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

J1-1 Chemical Structure

CAS No.: 1244769-10-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

J1-1 is an inhibitor of ICMT with an IC₅₀ of 1.0 μM and has anticancer activity^[1].

IC₅₀ & Target

IC50: 1.0 μM (ICMT)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	21.2 μM Compound: 1-2	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetric tetrazolium assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetric tetrazolium assay	[PMID: 20809634]
Sf9	IC₅₀	1 μM Compound: 1-2	Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting	[PMID: 20809634]

Chemical Information

CAS No. 1244769-10-5
분자량 376.53
화학식 C₂₅H₃₂N₂O
SMILES

O=C(N)CC1=CN(CCCCCCCC)C2=C1C=C(C3=CC=CC=C3C)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang WS et al. Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents. Amino Acids. 2017 Sep;49(9):1469-1485. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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