Jacaric acid
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC50 is 11.8 μM), LNCaP (IC50 is 2.2 μM) and DLD-1, induces apoptosis and necrosis. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator. Jacaric acid is orally active.
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- CAS No.: 28872-28-8
- 화학식: C18H30O2
- 분자량:278.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Jacaric acid (0-10 μM) dose- and time-dependently induces apoptosis in cells PC-3 and LNCaP, through an intrinsic and an intrinsic and extrinsic pathway, respectively[1].
Jacaric acid (0-10 μM) induces cytotoxicity in DLD-1 cells through intracellular incorporation and induction of apoptosis via lipid peroxidation[2].
Jacaric acid (50-100 μM) activates the macrophage through secretion of cytokines IFN-γ, IL-1β and TNF-α, enhances the endocytic activity in murine peritoneal macrophages and induces the cytostatic activity in MBL-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3, LNCaP
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Concentration:0-10 μM
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Incubation Time:24 h
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Result:Increased cleaved PARP and caspase 9 in PC-3 cells.
Increased cleaved PARP, caspase 8, caspase 9, p15 Bid and death receptor DR5 in LNCaP cells.
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Cell Line:PC-3, LNCaP, DLD-1
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Concentration:0-10 μM
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Incubation Time:24 h for cells PC-3 and LNCaP, 12 h for cell DLD-1
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Result:Induced apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DLD-1 xenograft athymic nude mice[2]
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Dosage:1 mg/mouse
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Administration:p.o. for 36 days
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Result:Reduced tumor volume without significant weight loss in body and liver.
Chemical Information
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CAS No. 28872-28-8
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분자량 278.43
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화학식 C18H30O2
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SMILES
CCCCC/C=C\C=C\C=C/CCCCCCC(O)=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Gasmi J, et al., Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 2013 Jun 15;20(8-9):734-42.. [Content Brief]
[2]. Shinohara N, et al., Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta. 2012 Jul;1821(7):980-8. [Content Brief]
[3]. Liu WN, et al., The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages. PLoS One. 2015 Dec 2;10(12):e0143684. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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