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Cat. No.: HY-N9861

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Kayaflavone

Name: Kayaflavone
Brand: MedChemExpress
SKU: HY-N9861
Price: 460.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

Kayaflavone is a biflavonoid compound from the seed kernel of Torreya grandis. Kayaflavone exhibits anticancer activity and is cytotoxic to human tumor cell lines. Kayaflavone inhibits amyloid-β toxicity in PC-12 cells with an EC₅₀ of 5.29 μM. Kayaflavone is predicted to bind to the catalytic site of the SARS-CoV-2 main protease (Mpro/3CLpro) and block enzyme activity, indicating potential antiviral activity. Kayaflavone can be used in cancer-related research, such as cervical cancer and breast cancer, as well as in research related to neurological diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 96.0%
CAS No.: 481-45-8
화학식: C₃₃H₂₄O₁₀
분자량:580.54

보관:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Kayaflavone Chemical Structure

CAS No.: 481-45-8

사이즈

가격

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수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	3.26 μg/mL	Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation. Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.	MGC-220077
MCF7	IC50	12.64 μg/mL	Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation. Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.	MGC-220077
PANC-1	IC50	16.44 μg/mL	Cytotoxicity against human pancreatic cancer PANC-1 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation. Cytotoxicity against human pancreatic cancer PANC-1 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.	MGC-220077
HepG2	IC50	8.67 μg/mL	Cytotoxicity against human hepatocellular carcinoma HepG-2 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation. Cytotoxicity against human hepatocellular carcinoma HepG-2 cells assessed by MTT colorimetric assay with absorbance at 570 nm after 48 hrs incubation.	MGC-220077

In Vitro

Kayaflavone (compound 2) (0.01-100 µg/mL; 48 h) exhibits cytotoxic activity against HeLa, MCF-7, PANC-1, and HepG-2 cells, with IC₅₀ values of 3.26, 12.64, 16.44, and 8.67 µg/mL, respectively, among which the activity against HeLa is the strongest^[1].
Kayaflavone (compound C9) (molecular docking simulation) yields a high predicted binding score (‑9.0351) against the SARS‑CoV‑2 main protease M^PRO^[2].
Kayaflavone (compound 15) inhibits amyloid-β toxicity in PC-12 cells, with an EC₅₀ of 5.29 μM, and cell viability reaches 80.5% at 10 μM^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HeLa, MCF-7, PANC-1, and HepG-2
Concentration:

0.01, 0.1, 1.0, 10.0, 100.0 µg/mL
Incubation Time:

48 h
Result:

Showed IC₅₀ values of 3.26 µg/mL against HeLa, 12.64 µg/mL against MCF-7, 16.44 µg/mL against PANC-1, and 8.67 µg/mL against HepG-2.

Related Protocols :

Chemical Information

CAS No. 481-45-8
Appearance Solid
분자량 580.54
화학식 C₃₃H₂₄O₁₀
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC(C3=C(C=C(C4=C3OC(C5=CC=C(OC)C=C5)=CC4=O)O)OC)=C(OC)C=C2)OC6=C1C(O)=CC(O)=C6
Structure Classification
- Flavonoids
- Flavones
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shen H, et al. Cytotoxic metabolites from the roots of Ranunculus ternatus. Chemistry of natural compounds. 2014 Oct;50(4):621-3.

[2]. Hossain R, et al. Amentoflavone derivatives against SARS-CoV-2 main protease (MPRO): An in silico study. Main Group Chemistry. 2023 Jun 16;22(2):313-27.

[3]. Yao H, et al. Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects. Molecules (Basel, Switzerland). 2017 Feb 20;22(2):325.

[4]. Sasaki H, et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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