KOSN 1724
KOSN 1724 is an anticancer agent. KOSN 1724 disrupts tubulin activity, stabilizes microtubules, and inhibits cancer cells proliferation. KOSN 1724 inhibits cytochrome P450 3A4, CYP2C9, and CYP2C19 activity. KOSN 1724 can be used for the research of cancer.
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- CAS No.: 693272-98-9
- 화학식: C27H39NO6
- 분자량:473.60
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
CYP3A4 7.1 μM (IC50) |
CYP2C19 10.9 μM (IC50) |
CYP2C9 12.9 μM (IC50) |
In Vitro
KOSN 1724 potently inhibits the proliferation of MCF-7, NCI/ADR, A549, and Skov cancer cell lines with IC50 values of 2.5, 6.1, 5.3 and 5.3 nM[1].
KOSN 1724 inhibits CYP3A4, CYP2C9, and CYP2C19 enzyme activity with IC50 values of 7.1 μM, 12.9 μM, and 10.9 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 693272-98-9
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분자량 473.60
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화학식 C27H39NO6
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SMILES
O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=NOC(C)=C2)C/C=C(C)\C/C=C/[C@H](C)[C@H](O)[C@@H](C)C1=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KOSN 1724 Related Classifications
HY-182602 Related Classifications
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