Kynuramine
Kynuramine is an endogenous amine that serves as a fluorescent substrate and probe for plasma amine oxidase.
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- CAS No.: 363-36-0
- 화학식: C9H12N2O
- 분자량:164.20
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Kynuramine inhibits both presynaptic and postsynaptic α-adrenoceptors in vitro[2].
Kynuramine has been shown to act as a partial agonist on serotonin receptors in dog cerebral arteries[2].
Kynuramine (20 μg/mL) causes a small contraction of the ileum but failed to alter the twitch response to cholinergic stimulation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Kynuramine (1.25-5.0 mg/kg; i.v.; single does) increases heart rate and blood pressure in rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female rats[3].
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Dosage:0.064, 0.32, 1.6 or 8 μg.
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Administration:Intraventricular injection; single does.
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Result:Produced facilitation of lordosis behavior.
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Animal Model:Male rats (about 200g)[4].
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Dosage:1.25, 2.5 and 5.0 mg/kg.
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Administration:Intravenous injection; single does.
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Result:Promoted heart rate and blood pressure.
Chemical Information
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CAS No. 363-36-0
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분자량 164.20
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화학식 C9H12N2O
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SMILES
O=C(CCN)C1=CC=CC=C1N
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Synonyms
Kynurenamine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [Content Brief]
[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [Content Brief]
[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [Content Brief]
[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kynuramine Related Classifications
HY-119395 Related Classifications
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