L-703606
L-703606 is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 144425-84-3
- 화학식: C27H29IN2
- 분자량:508.44
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| TAMH | IC50 |
17.2 μM
Compound: 4; L-703,606
|
Cytotoxicity against TAMH assessed as reduction in cell viability by CellTiter-Glo assay
Cytotoxicity against TAMH assessed as reduction in cell viability by CellTiter-Glo assay
|
[PMID: 27173385] |
| TAMH | IC50 |
64.28 μM
Compound: 4; L-703,606
|
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 10 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 10 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
|
[PMID: 27173385] |
| TAMH | IC50 |
78.19 μM
Compound: 4; L-703,606
|
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 1 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 1 uM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
|
[PMID: 27173385] |
| TAMH | IC50 |
80.9 μM
Compound: 4; L-703,606
|
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 100 nM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
Cytotoxicity against TAMH assessed as chloroquine IC50 by measuring reduction in cell viability at 100 nM by CellTiter-Glo assay (Rvb = 85.26 +/- 3.01 uM)
|
[PMID: 27173385] |
Chemical Information
-
CAS No. 144425-84-3
-
분자량 508.44
-
화학식 C27H29IN2
-
SMILES
IC(C=CC=C1)=C1CN[C@@H](C2CCN3CC2)[C@@H]3C(C4=CC=CC=C4)C5=CC=CC=C5
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Minowa S, et al. Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain. Eur J Pharmacol. 2004;486(3):317-324. [Content Brief]
[2]. Francis BE, et al. Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994;45(1):97-103. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-703606 Related Classifications
HY-117216 Related Classifications
Powered by Bioz