LM2I
Based on 1 Customer Validation
LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway.
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- Purity: 99.78%
- CAS No.: 2055494-50-1
- 화학식: C47H77N3O11
- 분자량:860.13
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보관:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Argininosuccinate synthetase (ASS1)[1]
LM2I (0µM~10µM, 48h) shows strong inhibitory effect in CRC cell lines[1].
LM2I (2µM, 15d) inhibits the EGFR pathway in colorectal cancer cells[1].
LM2I inhibits colorectal cancer cells via EGFR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CRC cell（HT29, SW480, SW620, HCT116, LoVo, RKO, and DLD1)
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Concentration:0µM,1.25µM,2.5µM,3.75µM,5.00µM,6.25µM,7.5µM,8.75µM,10µM
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Incubation Time:48h
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Result:Inhibited the viability of HT29, SW480, SW620, HCT116, LoVo, RKO, and DLD1 cells.
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Cell Line:HT29 and SW480 cells
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Concentration:0.75µM,1µM
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Incubation Time:14d
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Result:Had almost no effect on EGFR-KO cells.
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Cell Line:HT29, SW480, SW620, HCT116, LoVo, RKO, DLD1 cell
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Concentration:2µM
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Incubation Time:0~15d
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Result:EGFR protein levels were higher than control group.Time-dependently inhibited the protein levels of EGFR and significantly reduced relative to phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic BALB/c nude mice xenograft model(injected subcutaneously into the flank region with HT29 cell)[1].
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Dosage:2.5 mg/kg/day
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Administration:Intraperitoneal injection,every other day for 28 days
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Result:The tumor weight was significantly lower than that of the control group, and the tumor cell density was lower.
Chemical Information
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CAS No. 2055494-50-1
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Appearance Solid
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분자량 860.13
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화학식 C47H77N3O11
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Color White to off-white
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SMILES
O=C(C1=C[C@]2([H])[C@](C=C[C@@]3([H])[C@@]2([H])C[C@H](O[C@@H]4O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]4OC)C3)([H])[C@]1([H])C5)[C@H](C)[C@@H](O[C@@H]6O[C@H](C)[C@@H](N(CC(O)CN7CCNCC7)C)CC6)CCC[C@H](CC)OC5=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : ≥ 100 mg/mL (116.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1626 mL | 5.8131 mL | 11.6261 mL | 29.0654 mL |
| 5 mM | 0.2325 mL | 1.1626 mL | 2.3252 mL | 5.8131 mL | |
| 10 mM | 0.1163 mL | 0.5813 mL | 1.1626 mL | 2.9065 mL | |
| 15 mM | 0.0775 mL | 0.3875 mL | 0.7751 mL | 1.9377 mL | |
| 20 mM | 0.0581 mL | 0.2907 mL | 0.5813 mL | 1.4533 mL | |
| 25 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1626 mL | |
| 30 mM | 0.0388 mL | 0.1938 mL | 0.3875 mL | 0.9688 mL | |
| 40 mM | 0.0291 mL | 0.1453 mL | 0.2907 mL | 0.7266 mL | |
| 50 mM | 0.0233 mL | 0.1163 mL | 0.2325 mL | 0.5813 mL | |
| 60 mM | 0.0194 mL | 0.0969 mL | 0.1938 mL | 0.4844 mL | |
| 80 mM | 0.0145 mL | 0.0727 mL | 0.1453 mL | 0.3633 mL | |
| 100 mM | 0.0116 mL | 0.0581 mL | 0.1163 mL | 0.2907 mL |
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