LSALT peptide
LSALT peptide is a selective DPEP-1 inhibitor with selectivity over DPEP2/3. LSALT peptide inhibits neutrophil and monocyte/macrophage recruitment, inflammation, and tissue injury. LSALT peptide reduces kidney damage, improves survival in murine sepsis and endotoxemia models. LSALT peptide can be used for the research of COVID-19, sepsis, acute respiratory distress syndrome, and acute kidney injury.
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- CAS No.: 2567713-50-0
- 화학식: C85H136N20O21
- 분자량:1774.11
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
LSALT peptide binds specifically to human DPEP1, with no detectable binding to the closely related DPEP2 or DPEP3 proteins expressed on COS1 cells[2].
LSALT peptide (4 h) inhibits human neutrophil binding to pro-inflammatory stimulus-activated primary human lung endothelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
LSALT peptide (i.v.; single dose (5 minutes post-LPS) or two doses (5 minutes and 18 hours post-LPS)) significantly improves survival in a lethal murine endotoxemia model, and reduces LPS-induced acute lung injury[2].
LSALT peptide significantly reduces mortality and organ damage in a murine polymicrobial sepsis model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2567713-50-0
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분자량 1774.11
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화학식 C85H136N20O21
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SMILES
O=C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
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Sequence
Leu-Ser-Ala-Leu-Thr-Pro-Ser-Pro-Ser-Trp-Leu-Lys-Tyr-Lys-Ala-Leu-NH2
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Sequence Shortening
LSALTPSPSWLKYKAL-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Somayaji R, et al. Multicentre, randomised, double-blind, placebo-controlled, proof of concept study of LSALT peptide as prevention of acute respiratory distress syndrome and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19). BMJ Open. 2024;14(3):e076142. Published 2024 Mar 15. [Content Brief]
[2]. Choudhury SR, et al. Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver. Cell. 2019;178(5):1205-1221.e17. [Content Brief]
[3]. Hilpert K. Peptides in COVID-19 Clinical Trials—A Snapshot. Biologics. 2021; 1(3):300-311.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSALT peptide Related Classifications
HY-P11879 Related Classifications
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