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Cat. No.: HY-183552

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mCPX

mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX) (HY-B0450A). CPX exhibits bacteriostatic and iron-chelating activities, while mCPX enhances the iron stability of CPX. mCPX inherits the core mechanism pathway of CPX and can induce EBV lytic reactivation in EBV⁺ gastric cancer cells via the hypoxia pathway (HIF‑1α). mCPX is applicable to research related to EBV-positive gastric cancer.

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CAS No.: 1351572-56-9
화학식: C₁₄H₁₉NO₃
분자량:249.31

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

mCPX Chemical Structure

CAS No.: 1351572-56-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vitro

mCPX induces EBV lytic cycle in SNU719 and AGSBX1 EBV⁺ gastric cancer cell lines with activity comparable to CPX, and has significantly greater resistance to iron-mediated inactivation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC	AUC_0-∞	MRT	V_d	CL
Rat^[1]	14 mg/kg	i.p.	10.88 h	0.67 h	3085.04 μg/L	9195.38 μg/L·h	9455.28 μg/L·h	6.67 h	23.25 L/kg	1.48 L/h/kg
Rat^[1]	14 mg/kg	i.g.	5.01 h	1.50 h	511.88 μg/L	4332.53 μg/L·h	4350.86 μg/L·h	6.05 h	23.25 L/kg	3.22 L/h/kg

In Vivo

mCPX exhibits superior in vivo antitumor activity to CPX in the SNU719 xenograft mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1351572-56-9
분자량 249.31
화학식 C₁₄H₁₉NO₃
SMILES

O=C(C)ON(C(C1CCCCC1)=CC(C)=C2)C2=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhuang Y,et al. Targeting lytic cycle with ciclopirox derivative in Epstein-Barr Virus+ gastric cancer. Cancer Research. 2026 Apr 3;86(7_Supplement):213-.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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