Metaxalone-d6
Metaxalone-d6 is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia.
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- CAS No.: 1189944-95-3
- 화학식: C12H9D6NO3
- 분자량:227.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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HY-W028393
Indole-3-pyruvic acid -
HY-N1446S
Oleic acid-13C -
HY-W028393R
Indole-3-pyruvic acid (Standard) -
HY-N0583S2
Hydrocortisone-d4 -
HY-B0367S
Lornoxicam-d4 -
HY-B0916S
Propoxur-d3 -
HY-17589S
Chloroquine-d5 diphosphate -
HY-110231
Simvastatin-d6 -
HY-B1279AS
Metamizole-d3 sodium -
HY-B0335S
Tolfenamic acid-d4
Biological Activity
제품 설명
IC50 & Target
PPARγ and MAO-A[2]
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189944-95-3
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Unlabeled CAS 1665-48-1
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분자량 227.29
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화학식 C12H9D6NO3
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SMILES
[2H]C([2H])([2H])C1=CC(C([2H])([2H])[2H])=CC(OCC2OC(NC2)=O)=C1
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Synonyms
AHR438-d6; NSC170959-d6
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Pallio G, et al. MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells. Int J Mol Sci. 2021;22(16):8425. [Content Brief]
[3]. Stanko JR. Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner. Cranio. 1990 Jul;8(3):234-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Metaxalone-d6 Related Classifications
HY-B0678S1 Related Classifications
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