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Cat. No.: HY-120081

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Metixene

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

Metixene (Piperidine) is an anticholinergic and antiparkinsonian agent. Metixene potently inhibits binding of quinuclidinyl benzilate (QNB) with the muscarinic receptor, IC₅₀ and K_i values of 55 nM and 15 nM, respectively. Metixene can be used for the research of parkinsonian.

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CAS No.: 4969-02-2
화학식: C₂₀H₂₃NS
분자량:309.47

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Metixene Chemical Structure

CAS No.: 4969-02-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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제품 설명

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In Vitro

Metixene can potentially inhibit the binding of QNB with the muscarinic receptor, IC₅₀ and K_i values of 55 nM and 15 nM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 4969-02-2
분자량 309.47
화학식 C₂₀H₂₃NS
SMILES

CN1CC(CC2C3=C(SC4=C2C=CC=C4)C=CC=C3)CCC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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2025 Sep 9.
bioRxiv

Bepridil is potent against SARS-CoV-2 In Vitro. [Abstract]

2020 Jul 27:2020.05.23.112235. PMID: 32511370

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62(2):90-4. [Content Brief]

[2]. J. Hagenah, et al. Exogenous levodopa is not toxic to elderly subjects with non-parkinsonian movement disorders: further clinical evidence. , 106(3-4), 301–307. doi:10.1007/s007020050159

[3]. S L Levin, et al. Dualism in the effect of cholinolytics upon the human parotid gland deprived of parasympathetic control. Int J Clin Pharmacol Res. 1986;6(5):429-39. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Publications (2)
순도&문서
References

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Metixene

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All mAChR Isoforms