country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-14361

Copy Link Print Information

MK-4965

MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 920035-77-4
화학식: C₂₀H₁₃Cl₂N₅O₂
분자량:426.26

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MK-4965 Chemical Structure

CAS No.: 920035-77-4

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)^[1]

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
MT4	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
SUP-T1	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	>3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]

Chemical Information

CAS No. 920035-77-4
분자량 426.26
화학식 C₂₀H₁₃Cl₂N₅O₂
SMILES

N#CC1=CC(Cl)=CC(OC2=CC(OCC3=NNC4=NC(N)=CC=C43)=CC=C2Cl)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lai MT, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

MK-4965

All HIV Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

MK-4965 Related Classifications

HY-14361 Related Classifications